TY - CHAP
T1 - Constructing Realistic Canine Bilayer Biatrial Mesh for the Modeling and Simulation of Atria Fibrillation
AU - Saha, Mirabeau
AU - Roney, Caroline
AU - Xiong, Feng
AU - Cochet, Hubert
AU - Tan, Stephanie
AU - Niederer, Steven
AU - Vigmond, Edward
AU - Nattel, Stanley
N1 - Publisher Copyright:
© 2020 Creative Commons; the authors hold their copyright.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2020/9/13
Y1 - 2020/9/13
N2 - An improved appreciation of the mechanisms underlying atrial fibrillation (AF) is essential for better arrhythmia management. A deeper understanding requires a full consideration of atrial geometry. Here, we develop the first anatomically accurate high-resolution canine atrial computational bilayer model for AF studies. Canine CT-scan imaging data were segmented and used to reconstruct the Bachmann's bundle (BB), the left atrium (LA) and right atrium (RA). The LA is dilated to obtain the second layer. The RA endocardial layer consists of the sinus node (SAN), the pectinate muscles (PMs) and the crista terminalis (CT). The Ramirez-Nattel-Courtemanche canine cell model was used to simulate electrical activity. Activation time (AT) and action potential duration (APD) were computed. The obtained bilayer mesh has high resolution with average edge length 276±58µm. Action potential propagation from the SAN was realistic and its path along CS presumes an important role of the CS in the initiation and maintenance of rotors during AF. The propagation time from SAN to PVs was 119 ms and APD90 was heterogeneous in the model. This new bilayer model with realistic geometry, combined with experimental data, will help to better understand AF and its underlying mechanisms, in order to develop better prognostic and therapeutic tools.
AB - An improved appreciation of the mechanisms underlying atrial fibrillation (AF) is essential for better arrhythmia management. A deeper understanding requires a full consideration of atrial geometry. Here, we develop the first anatomically accurate high-resolution canine atrial computational bilayer model for AF studies. Canine CT-scan imaging data were segmented and used to reconstruct the Bachmann's bundle (BB), the left atrium (LA) and right atrium (RA). The LA is dilated to obtain the second layer. The RA endocardial layer consists of the sinus node (SAN), the pectinate muscles (PMs) and the crista terminalis (CT). The Ramirez-Nattel-Courtemanche canine cell model was used to simulate electrical activity. Activation time (AT) and action potential duration (APD) were computed. The obtained bilayer mesh has high resolution with average edge length 276±58µm. Action potential propagation from the SAN was realistic and its path along CS presumes an important role of the CS in the initiation and maintenance of rotors during AF. The propagation time from SAN to PVs was 119 ms and APD90 was heterogeneous in the model. This new bilayer model with realistic geometry, combined with experimental data, will help to better understand AF and its underlying mechanisms, in order to develop better prognostic and therapeutic tools.
UR - http://www.scopus.com/inward/record.url?scp=85100927521&partnerID=8YFLogxK
U2 - 10.22489/CinC.2020.070
DO - 10.22489/CinC.2020.070
M3 - Conference paper
AN - SCOPUS:85100927521
T3 - Computing in Cardiology
BT - 2020 Computing in Cardiology, CinC 2020
PB - IEEE Computer Society
T2 - 2020 Computing in Cardiology, CinC 2020
Y2 - 13 September 2020 through 16 September 2020
ER -