TY - JOUR
T1 - Contextual fear conditioning regulates the expression of brain-specific small nucleolar RNAs in hippocampus
AU - Rogelj, Boris
AU - Hartmann, Christoph E A
AU - Yeo, Christopher H
AU - Hunt, Stephen P
AU - Giese, K Peter
PY - 2003/12
Y1 - 2003/12
N2 - Some small nucleolar RNAs (snoRNAs) are exclusively expressed in the brain but they have no known role in higher brain function. We analysed the expression pattern of four brain-specific snoRNAs: MBI-36, MBII-48, MBII-52 and MBII-85, in mouse brain using in situ hybridization. All of these genes were expressed in the hippocampus and, except for MBII-85, their levels in ventral parts were higher than those in dorsal parts. Using quantitative real-time polymer chain reaction we determined hippocampal expression changes after contextual fear conditioning in mice. Ninety minutes, but not 25 h, after conditioning, we observed significant downregulation of MBII-48 and upregulation of MBII-52. Our finding that the expression of MBII-48 and MBII-52 is regulated during learning suggests that these snoRNAs have an important role in higher brain function.
AB - Some small nucleolar RNAs (snoRNAs) are exclusively expressed in the brain but they have no known role in higher brain function. We analysed the expression pattern of four brain-specific snoRNAs: MBI-36, MBII-48, MBII-52 and MBII-85, in mouse brain using in situ hybridization. All of these genes were expressed in the hippocampus and, except for MBII-85, their levels in ventral parts were higher than those in dorsal parts. Using quantitative real-time polymer chain reaction we determined hippocampal expression changes after contextual fear conditioning in mice. Ninety minutes, but not 25 h, after conditioning, we observed significant downregulation of MBII-48 and upregulation of MBII-52. Our finding that the expression of MBII-48 and MBII-52 is regulated during learning suggests that these snoRNAs have an important role in higher brain function.
U2 - 10.1111/j.1460-9568.2003.03026.x
DO - 10.1111/j.1460-9568.2003.03026.x
M3 - Article
C2 - 14656304
SN - 0953-816X
VL - 18
SP - 3089
EP - 3096
JO - European Journal of Neuroscience
JF - European Journal of Neuroscience
IS - 11
M1 - N/A
ER -