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Contrast-free high-resolution 3D magnetization transfer imaging for simultaneous myocardial scar and cardiac vein visualization

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Contrast-free high-resolution 3D magnetization transfer imaging for simultaneous myocardial scar and cardiac vein visualization. / López, Karina; Neji, Radhouene; Mukherjee, Rahul K; Whitaker, John; Phinikaridou, Alkystis; Razavi, Reza; Prieto, Claudia; Roujol, Sébastien; Botnar, René.

In: Magma: Magnetic Resonance Materials in Physics, Biology and Medicine, 20.02.2020.

Research output: Contribution to journalArticle

Harvard

López, K, Neji, R, Mukherjee, RK, Whitaker, J, Phinikaridou, A, Razavi, R, Prieto, C, Roujol, S & Botnar, R 2020, 'Contrast-free high-resolution 3D magnetization transfer imaging for simultaneous myocardial scar and cardiac vein visualization', Magma: Magnetic Resonance Materials in Physics, Biology and Medicine. https://doi.org/10.1007/s10334-020-00833-9

APA

López, K., Neji, R., Mukherjee, R. K., Whitaker, J., Phinikaridou, A., Razavi, R., ... Botnar, R. (2020). Contrast-free high-resolution 3D magnetization transfer imaging for simultaneous myocardial scar and cardiac vein visualization. Magma: Magnetic Resonance Materials in Physics, Biology and Medicine. https://doi.org/10.1007/s10334-020-00833-9

Vancouver

López K, Neji R, Mukherjee RK, Whitaker J, Phinikaridou A, Razavi R et al. Contrast-free high-resolution 3D magnetization transfer imaging for simultaneous myocardial scar and cardiac vein visualization. Magma: Magnetic Resonance Materials in Physics, Biology and Medicine. 2020 Feb 20. https://doi.org/10.1007/s10334-020-00833-9

Author

López, Karina ; Neji, Radhouene ; Mukherjee, Rahul K ; Whitaker, John ; Phinikaridou, Alkystis ; Razavi, Reza ; Prieto, Claudia ; Roujol, Sébastien ; Botnar, René. / Contrast-free high-resolution 3D magnetization transfer imaging for simultaneous myocardial scar and cardiac vein visualization. In: Magma: Magnetic Resonance Materials in Physics, Biology and Medicine. 2020.

Bibtex Download

@article{67b812f8694f4ad985b8e2011f4a60e4,
title = "Contrast-free high-resolution 3D magnetization transfer imaging for simultaneous myocardial scar and cardiac vein visualization",
abstract = "OBJECTIVE: To develop a three-dimensional (3D) high-resolution free-breathing magnetization transfer ratio (MTR) sequence for contrast-free assessment of myocardial infarct and coronary vein anatomy.MATERIALS AND METHODS: Two datasets with and without off-resonance magnetization transfer preparation were sequentially acquired to compute MTR. 2D image navigators enabled beat-to-beat translational and bin-to-bin non-rigid motion correction. Two different imaging sequences were explored. MTR scar localization was compared against 3D late gadolinium enhancement (LGE) in a porcine model of myocardial infarction. MTR variability across the left ventricle and vessel sharpness in the coronary veins were evaluated in healthy human subjects.RESULTS: A decrease in MTR was observed in areas with LGE in all pigs (non-infarct: 25.1 ± 1.7{\%} vs infarct: 16.8 ± 1.9{\%}). The average infarct volume overlap on MTR and LGE was 62.5 ± 19.2{\%}. In humans, mean MTR in myocardium was between 37 and 40{\%}. Spatial variability was between 15 and 20{\%} of the mean value. 3D whole heart MT-prepared datasets enabled coronary vein visualization with up to 8{\%} improved vessel sharpness for non-rigid compared to translational motion correction.DISCUSSION: MTR and LGE showed agreement in infarct detection and localization in a swine model. Free-breathing 3D MTR maps are feasible in humans but high spatial variability was observed. Further clinical studies are warranted.",
keywords = "Coronary vessels, Fibrosis, Magnetic resonance imaging",
author = "Karina L{\'o}pez and Radhouene Neji and Mukherjee, {Rahul K} and John Whitaker and Alkystis Phinikaridou and Reza Razavi and Claudia Prieto and S{\'e}bastien Roujol and Ren{\'e} Botnar",
year = "2020",
month = "2",
day = "20",
doi = "10.1007/s10334-020-00833-9",
language = "English",
journal = "Magma: Magnetic Resonance Materials in Physics, Biology and Medicine",
issn = "0968-5243",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Contrast-free high-resolution 3D magnetization transfer imaging for simultaneous myocardial scar and cardiac vein visualization

AU - López, Karina

AU - Neji, Radhouene

AU - Mukherjee, Rahul K

AU - Whitaker, John

AU - Phinikaridou, Alkystis

AU - Razavi, Reza

AU - Prieto, Claudia

AU - Roujol, Sébastien

AU - Botnar, René

PY - 2020/2/20

Y1 - 2020/2/20

N2 - OBJECTIVE: To develop a three-dimensional (3D) high-resolution free-breathing magnetization transfer ratio (MTR) sequence for contrast-free assessment of myocardial infarct and coronary vein anatomy.MATERIALS AND METHODS: Two datasets with and without off-resonance magnetization transfer preparation were sequentially acquired to compute MTR. 2D image navigators enabled beat-to-beat translational and bin-to-bin non-rigid motion correction. Two different imaging sequences were explored. MTR scar localization was compared against 3D late gadolinium enhancement (LGE) in a porcine model of myocardial infarction. MTR variability across the left ventricle and vessel sharpness in the coronary veins were evaluated in healthy human subjects.RESULTS: A decrease in MTR was observed in areas with LGE in all pigs (non-infarct: 25.1 ± 1.7% vs infarct: 16.8 ± 1.9%). The average infarct volume overlap on MTR and LGE was 62.5 ± 19.2%. In humans, mean MTR in myocardium was between 37 and 40%. Spatial variability was between 15 and 20% of the mean value. 3D whole heart MT-prepared datasets enabled coronary vein visualization with up to 8% improved vessel sharpness for non-rigid compared to translational motion correction.DISCUSSION: MTR and LGE showed agreement in infarct detection and localization in a swine model. Free-breathing 3D MTR maps are feasible in humans but high spatial variability was observed. Further clinical studies are warranted.

AB - OBJECTIVE: To develop a three-dimensional (3D) high-resolution free-breathing magnetization transfer ratio (MTR) sequence for contrast-free assessment of myocardial infarct and coronary vein anatomy.MATERIALS AND METHODS: Two datasets with and without off-resonance magnetization transfer preparation were sequentially acquired to compute MTR. 2D image navigators enabled beat-to-beat translational and bin-to-bin non-rigid motion correction. Two different imaging sequences were explored. MTR scar localization was compared against 3D late gadolinium enhancement (LGE) in a porcine model of myocardial infarction. MTR variability across the left ventricle and vessel sharpness in the coronary veins were evaluated in healthy human subjects.RESULTS: A decrease in MTR was observed in areas with LGE in all pigs (non-infarct: 25.1 ± 1.7% vs infarct: 16.8 ± 1.9%). The average infarct volume overlap on MTR and LGE was 62.5 ± 19.2%. In humans, mean MTR in myocardium was between 37 and 40%. Spatial variability was between 15 and 20% of the mean value. 3D whole heart MT-prepared datasets enabled coronary vein visualization with up to 8% improved vessel sharpness for non-rigid compared to translational motion correction.DISCUSSION: MTR and LGE showed agreement in infarct detection and localization in a swine model. Free-breathing 3D MTR maps are feasible in humans but high spatial variability was observed. Further clinical studies are warranted.

KW - Coronary vessels

KW - Fibrosis

KW - Magnetic resonance imaging

UR - http://www.scopus.com/inward/record.url?scp=85079771181&partnerID=8YFLogxK

U2 - 10.1007/s10334-020-00833-9

DO - 10.1007/s10334-020-00833-9

M3 - Article

C2 - 32078075

JO - Magma: Magnetic Resonance Materials in Physics, Biology and Medicine

JF - Magma: Magnetic Resonance Materials in Physics, Biology and Medicine

SN - 0968-5243

ER -

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