Contribution of Common Genetic Variants to Antidepressant Response

Katherine E Tansey; Michel Guipponi; Xiaolan Hu; Enrico Domenici; Glyn Lewis; Alain Malafosse; Jens R Wendland; Cathryn M Lewis; Peter McGuffin; Rudolf Uher

doi:10.1016/j.biopsych.2012.10.030

Contribution of Common Genetic Variants to Antidepressant Response

Katherine E Tansey, Michel Guipponi, Xiaolan Hu, Enrico Domenici, Glyn Lewis, Alain Malafosse, Jens R Wendland, Cathryn M Lewis, Peter McGuffin, Rudolf Uher

Research output: Contribution to journal › Article › peer-review

195 Citations (Scopus)

Abstract

Background
Pharmacogenetic studies aiming to personalize the treatment of depression are based on the assumption that response to antidepressants is a heritable trait, but there is no compelling evidence to support this.

Methods
We estimate the contribution of common genetic variation to antidepressant response with Genome-Wide Complex Trait Analysis in a combined sample of 2799 antidepressant-treated subjects with major depressive disorder and genome-wide genotype data.

Results
We find that common genetic variants explain 42% (SE = .180, p = .009) of individual differences in antidepressant response.

Conclusions
These results suggest that response to antidepressants is a complex trait with substantial contribution from a large number of common genetic variants of small effect.

Original language	English
Article number	N/A
Pages (from-to)	679-682
Number of pages	4
Journal	Biological psychiatry
Volume	73
Issue number	7
Early online date	11 Dec 2012
DOIs	https://doi.org/10.1016/j.biopsych.2012.10.030
Publication status	Published - 1 Apr 2013

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10.1016/j.biopsych.2012.10.030

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title = "Contribution of Common Genetic Variants to Antidepressant Response",

abstract = "BackgroundPharmacogenetic studies aiming to personalize the treatment of depression are based on the assumption that response to antidepressants is a heritable trait, but there is no compelling evidence to support this.MethodsWe estimate the contribution of common genetic variation to antidepressant response with Genome-Wide Complex Trait Analysis in a combined sample of 2799 antidepressant-treated subjects with major depressive disorder and genome-wide genotype data.ResultsWe find that common genetic variants explain 42% (SE = .180, p = .009) of individual differences in antidepressant response.ConclusionsThese results suggest that response to antidepressants is a complex trait with substantial contribution from a large number of common genetic variants of small effect.",

author = "Tansey, {Katherine E} and Michel Guipponi and Xiaolan Hu and Enrico Domenici and Glyn Lewis and Alain Malafosse and Wendland, {Jens R} and Lewis, {Cathryn M} and Peter McGuffin and Rudolf Uher",

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T1 - Contribution of Common Genetic Variants to Antidepressant Response

AU - Tansey, Katherine E

AU - Guipponi, Michel

AU - Hu, Xiaolan

AU - Domenici, Enrico

AU - Lewis, Glyn

AU - Malafosse, Alain

AU - Wendland, Jens R

AU - Lewis, Cathryn M

AU - McGuffin, Peter

AU - Uher, Rudolf

PY - 2013/4/1

Y1 - 2013/4/1

N2 - BackgroundPharmacogenetic studies aiming to personalize the treatment of depression are based on the assumption that response to antidepressants is a heritable trait, but there is no compelling evidence to support this.MethodsWe estimate the contribution of common genetic variation to antidepressant response with Genome-Wide Complex Trait Analysis in a combined sample of 2799 antidepressant-treated subjects with major depressive disorder and genome-wide genotype data.ResultsWe find that common genetic variants explain 42% (SE = .180, p = .009) of individual differences in antidepressant response.ConclusionsThese results suggest that response to antidepressants is a complex trait with substantial contribution from a large number of common genetic variants of small effect.

AB - BackgroundPharmacogenetic studies aiming to personalize the treatment of depression are based on the assumption that response to antidepressants is a heritable trait, but there is no compelling evidence to support this.MethodsWe estimate the contribution of common genetic variation to antidepressant response with Genome-Wide Complex Trait Analysis in a combined sample of 2799 antidepressant-treated subjects with major depressive disorder and genome-wide genotype data.ResultsWe find that common genetic variants explain 42% (SE = .180, p = .009) of individual differences in antidepressant response.ConclusionsThese results suggest that response to antidepressants is a complex trait with substantial contribution from a large number of common genetic variants of small effect.

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DO - 10.1016/j.biopsych.2012.10.030

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SN - 0006-3223

VL - 73

SP - 679

EP - 682

JO - Biological psychiatry

JF - Biological psychiatry

IS - 7

M1 - N/A

ER -

Contribution of Common Genetic Variants to Antidepressant Response

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