Control of HIV-1 gene expression by SR proteins

TY - JOUR

T1 - Control of HIV-1 gene expression by SR proteins

AU - Mahiet, Charlotte

AU - Swanson, Chad M.

PY - 2016/10/15

Y1 - 2016/10/15

N2 - Cellular proteins are required for all steps of human immunodeficiency virus type 1 (HIV-1) gene expression including transcription, splicing, 3'-end formation/polyadenylation, nuclear export and translation. SR proteins are a family of cellular RNA-binding proteins that regulate and functionally integrate multiple steps of gene expression. Specific SR proteins are best characterised for regulating HIV-1 RNA splicing by binding specific locations in the viral RNA, though recently they have also been shown to control transcription, 30-end formation, and translation. Due to their importance in regulating HIV-1 gene expression, SR proteins and their regulatory factors are potential antiviral drug targets.

AB - Cellular proteins are required for all steps of human immunodeficiency virus type 1 (HIV-1) gene expression including transcription, splicing, 3'-end formation/polyadenylation, nuclear export and translation. SR proteins are a family of cellular RNA-binding proteins that regulate and functionally integrate multiple steps of gene expression. Specific SR proteins are best characterised for regulating HIV-1 RNA splicing by binding specific locations in the viral RNA, though recently they have also been shown to control transcription, 30-end formation, and translation. Due to their importance in regulating HIV-1 gene expression, SR proteins and their regulatory factors are potential antiviral drug targets.

UR - http://www.scopus.com/inward/record.url?scp=85009799943&partnerID=8YFLogxK

U2 - 10.1042/BST20160113

DO - 10.1042/BST20160113

M3 - Article

AN - SCOPUS:85009799943

SN - 0300-5127

VL - 44

SP - 1417

EP - 1425

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 5

ER -