Controversies in bipolar disorder; role of second-generation antipsychotic for maintenance therapy

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Abstract

In this narrative review, we discuss use of second-generation antipsychotics (SGAs) in maintenance treatment of bipolar disorder. We compare their use to historically more established treatments (particularly lithium, the gold standard). To compare we review evidence on efficacy, effectiveness and tolerability across illness poles, possible mechanisms of treatment response, guidance given by guideline groups and pragmatic clinical considerations. We then illustrate the controversies in maintenance antipsychotic use, with the example of first episode mania and its treatment within first episode psychosis services. Finally, we make suggestions for future studies to unpick these differences.

Original languageEnglish
Article number10
JournalInternational Journal of Bipolar Disorders
Volume7
Issue number1
DOIs
Publication statusPublished - 27 Mar 2019

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