TY - JOUR
T1 - Controversies in bipolar disorder; role of second-generation antipsychotic for maintenance therapy
AU - Jauhar, Sameer
AU - Young, Allan H.
PY - 2019/3/27
Y1 - 2019/3/27
N2 - In this narrative review, we discuss use of second-generation antipsychotics (SGAs) in maintenance treatment of bipolar disorder. We compare their use to historically more established treatments (particularly lithium, the gold standard). To compare we review evidence on efficacy, effectiveness and tolerability across illness poles, possible mechanisms of treatment response, guidance given by guideline groups and pragmatic clinical considerations. We then illustrate the controversies in maintenance antipsychotic use, with the example of first episode mania and its treatment within first episode psychosis services. Finally, we make suggestions for future studies to unpick these differences.
AB - In this narrative review, we discuss use of second-generation antipsychotics (SGAs) in maintenance treatment of bipolar disorder. We compare their use to historically more established treatments (particularly lithium, the gold standard). To compare we review evidence on efficacy, effectiveness and tolerability across illness poles, possible mechanisms of treatment response, guidance given by guideline groups and pragmatic clinical considerations. We then illustrate the controversies in maintenance antipsychotic use, with the example of first episode mania and its treatment within first episode psychosis services. Finally, we make suggestions for future studies to unpick these differences.
UR - http://www.scopus.com/inward/record.url?scp=85063585167&partnerID=8YFLogxK
U2 - 10.1186/s40345-019-0145-0
DO - 10.1186/s40345-019-0145-0
M3 - Review article
C2 - 30915592
SN - 2194-7511
VL - 7
JO - International Journal of Bipolar Disorders
JF - International Journal of Bipolar Disorders
IS - 1
M1 - 10
ER -