Copper(II) cyclam-based complexes for radiopharmaceutical applications: Synthesis and structural analysis

Jon D. Silversides; Cheryll C. Allan; Stephen J. Archibald

doi:10.1039/b615329a

Copper(II) cyclam-based complexes for radiopharmaceutical applications: Synthesis and structural analysis

Jon D. Silversides, Cheryll C. Allan, Stephen J. Archibald^*

^*Corresponding author for this work

Imaging Chemistry & Biology

Research output: Contribution to journal › Article › peer-review

84 Citations (Scopus)

Abstract

Two molecular structures of the copper(ii) complex, Cu(H₂TETA), have been determined by X-ray crystallography. The Jahn-Teller distortion differs between the two structures; occurring either along the axis of the pendant acetate arms or across the macrocyclic ring. An analysis of deposited data from over one hundred copper(ii) cyclam X-ray structures in the Cambridge Structural Database (CSD) reveals that Jahn-Teller distortion across the ring is highly unusual for such compounds in the solid state. Novel chelators based on the piperazino/side-bridged cyclam have been prepared and copper(ii) complexes formed. The single crystal X-ray structures of two copper(ii) complexes, with either an ester or acid N-pendant arm, have been determined and in both cases the pendant arm is bound to the metal centre.

Original language	English
Pages (from-to)	971-978
Number of pages	8
Journal	Dalton Transactions
Issue number	9
DOIs	https://doi.org/10.1039/b615329a
Publication status	Published - 2007

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abstract = "Two molecular structures of the copper(ii) complex, Cu(H2TETA), have been determined by X-ray crystallography. The Jahn-Teller distortion differs between the two structures; occurring either along the axis of the pendant acetate arms or across the macrocyclic ring. An analysis of deposited data from over one hundred copper(ii) cyclam X-ray structures in the Cambridge Structural Database (CSD) reveals that Jahn-Teller distortion across the ring is highly unusual for such compounds in the solid state. Novel chelators based on the piperazino/side-bridged cyclam have been prepared and copper(ii) complexes formed. The single crystal X-ray structures of two copper(ii) complexes, with either an ester or acid N-pendant arm, have been determined and in both cases the pendant arm is bound to the metal centre.",

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T1 - Copper(II) cyclam-based complexes for radiopharmaceutical applications

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AU - Silversides, Jon D.

AU - Allan, Cheryll C.

AU - Archibald, Stephen J.

PY - 2007

Y1 - 2007

N2 - Two molecular structures of the copper(ii) complex, Cu(H2TETA), have been determined by X-ray crystallography. The Jahn-Teller distortion differs between the two structures; occurring either along the axis of the pendant acetate arms or across the macrocyclic ring. An analysis of deposited data from over one hundred copper(ii) cyclam X-ray structures in the Cambridge Structural Database (CSD) reveals that Jahn-Teller distortion across the ring is highly unusual for such compounds in the solid state. Novel chelators based on the piperazino/side-bridged cyclam have been prepared and copper(ii) complexes formed. The single crystal X-ray structures of two copper(ii) complexes, with either an ester or acid N-pendant arm, have been determined and in both cases the pendant arm is bound to the metal centre.

AB - Two molecular structures of the copper(ii) complex, Cu(H2TETA), have been determined by X-ray crystallography. The Jahn-Teller distortion differs between the two structures; occurring either along the axis of the pendant acetate arms or across the macrocyclic ring. An analysis of deposited data from over one hundred copper(ii) cyclam X-ray structures in the Cambridge Structural Database (CSD) reveals that Jahn-Teller distortion across the ring is highly unusual for such compounds in the solid state. Novel chelators based on the piperazino/side-bridged cyclam have been prepared and copper(ii) complexes formed. The single crystal X-ray structures of two copper(ii) complexes, with either an ester or acid N-pendant arm, have been determined and in both cases the pendant arm is bound to the metal centre.

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Copper(II) cyclam-based complexes for radiopharmaceutical applications: Synthesis and structural analysis

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