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Coronary Microcirculation in Aortic Stenosis: A Physiological Hornets' Nest

Research output: Contribution to journalReview articlepeer-review

Hannah Z.R. McConkey, Michael Marber, Amedeo Chiribiri, Philippe Pibarot, Simon R. Redwood, Bernard D. Prendergast

Original languageEnglish
Article numbere007547
Pages (from-to)e007547
JournalCirculation. Cardiovascular interventions
Volume12
Issue number8
DOIs
Accepted/In press16 Jan 2019
Published16 Aug 2019

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Abstract

Aortic stenosis is a heterogeneous disorder. Variations in the pathological and physiological responses to pressure overload are incompletely understood and generate a range of flow and pressure gradient patterns, which ultimately cause varying microvascular effects. The impact of cardiac-coronary coupling depends on these pressure and flow effects. In this article, we explore important concepts concerning cardiac physiology and the coronary microcirculation in aortic stenosis and their impact on myocardial remodeling, aortic valve flow patterns, and clinical progression.

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