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Correlates of vitamin D in psychotic disorders: A comprehensive systematic review

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)78-85
Number of pages8
JournalPsychiatry Research
Early online date31 Dec 2016
Accepted/In press30 Dec 2016
E-pub ahead of print31 Dec 2016
Published1 Mar 2017


  • Correlates of vitamin D_ADAMSON_Accepted30December2016_GREEN AAM (CC BY-NC-ND)

    Correlates_of_vitamin_D_ADAMSON_Accepted30December2016_GREEN_AAM_CC_BY_NC_ND_.pdf, 430 KB, application/pdf

    Uploaded date:26 Apr 2018

    Version:Accepted author manuscript

    Licence:CC BY-NC-ND

    © <2017> This manuscript version is made available under the CC-BY-NC-ND 4.0 license

King's Authors


People with psychosis have high prevalence of low vitamin D levels but the correlates and relevance of this deficiency are unclear. A systematic search of major databases from inception to 03/2016 was undertaken investigating correlates of vitamin D in people with psychosis. Data was summarised with a best evidence synthesis. Across 23 included studies (n=1770 psychosis, n=8171 controls) a mean difference in vitamin D levels between both groups of −11.14 ng/ml±0.59 was found. 53 unique correlations between vitamin D and outcomes in people with psychosis were identified. The evidence base was broadly equivocal although season of blood sampling (67% of studies found a positive correlation with warmer seasons) and parathyroid hormone (100% of studies found a negative correlation) were associated with vitamin D levels. The most commonly non-correlated variables were: BMI (83% found no correlation), age (73%), gender (86%), smoking (100%), duration of illness (100%) and general assessment of functioning score (100%). In conclusion, whilst many unique correlates have been investigated, there is weak and inconclusive evidence regarding the consistency and meaning of the correlates of vitamin D levels in people with psychosis. Future longitudinal studies should consider the correlates of vitamin D in people with psychosis.

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