Abstract
People with psychosis have high prevalence of low vitamin D levels but the correlates and relevance of this deficiency are unclear. A systematic search of major databases from inception to 03/2016 was undertaken investigating correlates of vitamin D in people with psychosis. Data was summarised with a best evidence synthesis. Across 23 included studies (n=1770 psychosis, n=8171 controls) a mean difference in vitamin D levels between both groups of −11.14 ng/ml±0.59 was found. 53 unique correlations between vitamin D and outcomes in people with psychosis were identified. The evidence base was broadly equivocal although season of blood sampling (67% of studies found a positive correlation with warmer seasons) and parathyroid hormone (100% of studies found a negative correlation) were associated with vitamin D levels. The most commonly non-correlated variables were: BMI (83% found no correlation), age (73%), gender (86%), smoking (100%), duration of illness (100%) and general assessment of functioning score (100%). In conclusion, whilst many unique correlates have been investigated, there is weak and inconclusive evidence regarding the consistency and meaning of the correlates of vitamin D levels in people with psychosis. Future longitudinal studies should consider the correlates of vitamin D in people with psychosis.
| Original language | English |
|---|---|
| Pages (from-to) | 78-85 |
| Number of pages | 8 |
| Journal | Psychiatry Research |
| Volume | 249 |
| Early online date | 31 Dec 2016 |
| DOIs | |
| Publication status | Published - 1 Mar 2017 |
Keywords
- 25-hydroxyvitamin D
- 25-OHD
- Hypovitaminosis D
- Psychosis
- Schizophrenia
- Vitamin D
Access to Document
- Correlates of vitamin D_ADAMSON_Accepted30December2016_GREEN AAM (CC BY-NC-ND)
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