Cortical effects of quetiapine in first-episode schizophrenia: A preliminary functional magnetic resonance imaging study

TY - JOUR

T1 - Cortical effects of quetiapine in first-episode schizophrenia: A preliminary functional magnetic resonance imaging study

AU - Jones, H M

AU - Brammer, M J

AU - O'Toole, M

AU - Taylor, T

AU - Ohlsen, R I

AU - Brown, R G

AU - Purvis, R

AU - Williams, S

AU - Pilowsky, L S

PY - 2004/12/15

Y1 - 2004/12/15

N2 - Background: Quetiapine improves both psychotic symptoms and cognitive function in schizophrenia. The neural basis of these actions is poorly understood. Methods: Three subject groups underwent a single functional magnetic resonance imaging (fMRI) session: drug-naive (n = 7) and quetiapine-treated samples of patients with schizophrenia (n = 8)and a healthy control group (n = 8). The fMRI session included an overt verbal fluency task and a passive auditory stimulation task. Results: In the verbal fluency task, There was significantly increased activation in the left inferior frontal cortex in the quetiapine-treated patient, and the healthy control sample compared with the drug-naive sample. During auditory stimulation, the healthy control group and stably treated group produced significantly greater activation in the superior temporal gyrus than the drug-naive sample. Conclusions: Quetiapine treatment is associated with altered blood oxygen level-dependent responses in both the prefrontal and temporal cortex that cannot be accounted,for by improved task performance subsequent to drug treatment.

AB - Background: Quetiapine improves both psychotic symptoms and cognitive function in schizophrenia. The neural basis of these actions is poorly understood. Methods: Three subject groups underwent a single functional magnetic resonance imaging (fMRI) session: drug-naive (n = 7) and quetiapine-treated samples of patients with schizophrenia (n = 8)and a healthy control group (n = 8). The fMRI session included an overt verbal fluency task and a passive auditory stimulation task. Results: In the verbal fluency task, There was significantly increased activation in the left inferior frontal cortex in the quetiapine-treated patient, and the healthy control sample compared with the drug-naive sample. During auditory stimulation, the healthy control group and stably treated group produced significantly greater activation in the superior temporal gyrus than the drug-naive sample. Conclusions: Quetiapine treatment is associated with altered blood oxygen level-dependent responses in both the prefrontal and temporal cortex that cannot be accounted,for by improved task performance subsequent to drug treatment.

U2 - 10.1016/j.biopsych.2004.08.006

DO - 10.1016/j.biopsych.2004.08.006

M3 - Article

SN - 1873-2402

VL - 56

SP - 938

EP - 942

JO - Biological psychiatry

JF - Biological psychiatry

IS - 12

ER -