Cortical involvement in four cases of primary lateral sclerosis using [C-11]-flumazenil PET

M R Turner, A Hammers, A Al-Chalabi, C E Shaw, P M Andersen, D J Brooks, P N Leigh

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


Four PLS patients underwent cerebral [C-11]-flumazenil PET. They were compared firstly with a group of controls, then later directly with a group of sporadic ALS patients and a familial ALS group homozygous for the 'D90A' SOD1 gene mutation. There was a similar pattern of decreased binding in PLS patients when compared to controls as that seen in a previous study of sporadic ALS patients, supporting the concept that PLS is part of the same overall spectrum of MND. However, in direct group comparisons, both sporadic and homD90A ALS patients demonstrated relative decreases in anterior and orbito-frontal binding compared to PLS patients, suggesting that there may be differences in cortical vulnerability between phenotypic groups
Original languageEnglish
Pages (from-to)1033 - 1036
Number of pages4
JournalJournal of Neurology
Issue number8
Publication statusPublished - Aug 2007


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