Cortical microstructure in young onset Alzheimer's disease using neurite orientation dispersion and density imaging

Thomas D. Parker; Catherine F. Slattery; Jiaying Zhang; Jennifer M. Nicholas; Ross W. Paterson; Alexander J.M. Foulkes; Ian B. Malone; David L. Thomas; Marc Modat; David M. Cash; Sebastian J. Crutch; Daniel C. Alexander; Sebastien Ourselin; Nick C. Fox; Hui Zhang; Jonathan M. Schott

doi:10.1002/hbm.24056

Cortical microstructure in young onset Alzheimer's disease using neurite orientation dispersion and density imaging

Thomas D. Parker^*, Catherine F. Slattery, Jiaying Zhang, Jennifer M. Nicholas, Ross W. Paterson, Alexander J.M. Foulkes, Ian B. Malone, David L. Thomas, Marc Modat, David M. Cash, Sebastian J. Crutch, Daniel C. Alexander, Sebastien Ourselin, Nick C. Fox, Hui Zhang, Jonathan M. Schott

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

84 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is associated with extensive alterations in grey matter microstructure, but our ability to quantify this in vivo is limited. Neurite orientation dispersion and density imaging (NODDI) is a multi-shell diffusion MRI technique that estimates neuritic microstructure in the form of orientation dispersion and neurite density indices (ODI/NDI). Mean values for cortical thickness, ODI, and NDI were extracted from predefined regions of interest in the cortical grey matter of 38 patients with young onset AD and 22 healthy controls. Five cortical regions associated with early atrophy in AD (entorhinal cortex, inferior temporal gyrus, middle temporal gyrus, fusiform gyrus, and precuneus) and one region relatively spared from atrophy in AD (precentral gyrus) were investigated. ODI, NDI, and cortical thickness values were compared between controls and patients for each region, and their associations with MMSE score were assessed. NDI values of all regions were significantly lower in patients. Cortical thickness measurements were significantly lower in patients in regions associated with early atrophy in AD, but not in the precentral gyrus. Decreased ODI was evident in patients in the inferior and middle temporal gyri, fusiform gyrus, and precuneus. The majority of AD-related decreases in cortical ODI and NDI persisted following adjustment for cortical thickness, as well as each other. There was evidence in the patient group that cortical NDI was associated with MMSE performance. These data suggest distinct differences in cortical NDI and ODI occur in AD and these metrics provide pathologically relevant information beyond that of cortical thinning.

Original language	English
Journal	Human Brain Mapping
Early online date	25 Mar 2018
DOIs	https://doi.org/10.1002/hbm.24056
Publication status	E-pub ahead of print - 25 Mar 2018

Keywords

Alzheimer's disease
Dementia
Diffusion MRI
Grey matter
Neurite orientation dispersion and density imaging
Neurodegenerative disorders

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Parker, T. D., Slattery, C. F., Zhang, J., Nicholas, J. M., Paterson, R. W., Foulkes, A. J. M., Malone, I. B., Thomas, D. L., Modat, M., Cash, D. M., Crutch, S. J., Alexander, D. C., Ourselin, S., Fox, N. C., Zhang, H., & Schott, J. M. (2018). Cortical microstructure in young onset Alzheimer's disease using neurite orientation dispersion and density imaging. Human Brain Mapping. Advance online publication. https://doi.org/10.1002/hbm.24056

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title = "Cortical microstructure in young onset Alzheimer's disease using neurite orientation dispersion and density imaging",

abstract = "Alzheimer's disease (AD) is associated with extensive alterations in grey matter microstructure, but our ability to quantify this in vivo is limited. Neurite orientation dispersion and density imaging (NODDI) is a multi-shell diffusion MRI technique that estimates neuritic microstructure in the form of orientation dispersion and neurite density indices (ODI/NDI). Mean values for cortical thickness, ODI, and NDI were extracted from predefined regions of interest in the cortical grey matter of 38 patients with young onset AD and 22 healthy controls. Five cortical regions associated with early atrophy in AD (entorhinal cortex, inferior temporal gyrus, middle temporal gyrus, fusiform gyrus, and precuneus) and one region relatively spared from atrophy in AD (precentral gyrus) were investigated. ODI, NDI, and cortical thickness values were compared between controls and patients for each region, and their associations with MMSE score were assessed. NDI values of all regions were significantly lower in patients. Cortical thickness measurements were significantly lower in patients in regions associated with early atrophy in AD, but not in the precentral gyrus. Decreased ODI was evident in patients in the inferior and middle temporal gyri, fusiform gyrus, and precuneus. The majority of AD-related decreases in cortical ODI and NDI persisted following adjustment for cortical thickness, as well as each other. There was evidence in the patient group that cortical NDI was associated with MMSE performance. These data suggest distinct differences in cortical NDI and ODI occur in AD and these metrics provide pathologically relevant information beyond that of cortical thinning.",

keywords = "Alzheimer's disease, Dementia, Diffusion MRI, Grey matter, Neurite orientation dispersion and density imaging, Neurodegenerative disorders",

author = "Parker, {Thomas D.} and Slattery, {Catherine F.} and Jiaying Zhang and Nicholas, {Jennifer M.} and Paterson, {Ross W.} and Foulkes, {Alexander J.M.} and Malone, {Ian B.} and Thomas, {David L.} and Marc Modat and Cash, {David M.} and Crutch, {Sebastian J.} and Alexander, {Daniel C.} and Sebastien Ourselin and Fox, {Nick C.} and Hui Zhang and Schott, {Jonathan M.}",

year = "2018",

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doi = "10.1002/hbm.24056",

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journal = "Human Brain Mapping",

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Parker, TD, Slattery, CF, Zhang, J, Nicholas, JM, Paterson, RW, Foulkes, AJM, Malone, IB, Thomas, DL, Modat, M, Cash, DM, Crutch, SJ, Alexander, DC, Ourselin, S, Fox, NC, Zhang, H & Schott, JM 2018, 'Cortical microstructure in young onset Alzheimer's disease using neurite orientation dispersion and density imaging', Human Brain Mapping. https://doi.org/10.1002/hbm.24056

TY - JOUR

T1 - Cortical microstructure in young onset Alzheimer's disease using neurite orientation dispersion and density imaging

AU - Parker, Thomas D.

AU - Slattery, Catherine F.

AU - Zhang, Jiaying

AU - Nicholas, Jennifer M.

AU - Paterson, Ross W.

AU - Foulkes, Alexander J.M.

AU - Malone, Ian B.

AU - Thomas, David L.

AU - Modat, Marc

AU - Cash, David M.

AU - Crutch, Sebastian J.

AU - Alexander, Daniel C.

AU - Ourselin, Sebastien

AU - Fox, Nick C.

AU - Zhang, Hui

AU - Schott, Jonathan M.

PY - 2018/3/25

Y1 - 2018/3/25

N2 - Alzheimer's disease (AD) is associated with extensive alterations in grey matter microstructure, but our ability to quantify this in vivo is limited. Neurite orientation dispersion and density imaging (NODDI) is a multi-shell diffusion MRI technique that estimates neuritic microstructure in the form of orientation dispersion and neurite density indices (ODI/NDI). Mean values for cortical thickness, ODI, and NDI were extracted from predefined regions of interest in the cortical grey matter of 38 patients with young onset AD and 22 healthy controls. Five cortical regions associated with early atrophy in AD (entorhinal cortex, inferior temporal gyrus, middle temporal gyrus, fusiform gyrus, and precuneus) and one region relatively spared from atrophy in AD (precentral gyrus) were investigated. ODI, NDI, and cortical thickness values were compared between controls and patients for each region, and their associations with MMSE score were assessed. NDI values of all regions were significantly lower in patients. Cortical thickness measurements were significantly lower in patients in regions associated with early atrophy in AD, but not in the precentral gyrus. Decreased ODI was evident in patients in the inferior and middle temporal gyri, fusiform gyrus, and precuneus. The majority of AD-related decreases in cortical ODI and NDI persisted following adjustment for cortical thickness, as well as each other. There was evidence in the patient group that cortical NDI was associated with MMSE performance. These data suggest distinct differences in cortical NDI and ODI occur in AD and these metrics provide pathologically relevant information beyond that of cortical thinning.

AB - Alzheimer's disease (AD) is associated with extensive alterations in grey matter microstructure, but our ability to quantify this in vivo is limited. Neurite orientation dispersion and density imaging (NODDI) is a multi-shell diffusion MRI technique that estimates neuritic microstructure in the form of orientation dispersion and neurite density indices (ODI/NDI). Mean values for cortical thickness, ODI, and NDI were extracted from predefined regions of interest in the cortical grey matter of 38 patients with young onset AD and 22 healthy controls. Five cortical regions associated with early atrophy in AD (entorhinal cortex, inferior temporal gyrus, middle temporal gyrus, fusiform gyrus, and precuneus) and one region relatively spared from atrophy in AD (precentral gyrus) were investigated. ODI, NDI, and cortical thickness values were compared between controls and patients for each region, and their associations with MMSE score were assessed. NDI values of all regions were significantly lower in patients. Cortical thickness measurements were significantly lower in patients in regions associated with early atrophy in AD, but not in the precentral gyrus. Decreased ODI was evident in patients in the inferior and middle temporal gyri, fusiform gyrus, and precuneus. The majority of AD-related decreases in cortical ODI and NDI persisted following adjustment for cortical thickness, as well as each other. There was evidence in the patient group that cortical NDI was associated with MMSE performance. These data suggest distinct differences in cortical NDI and ODI occur in AD and these metrics provide pathologically relevant information beyond that of cortical thinning.

KW - Alzheimer's disease

KW - Dementia

KW - Diffusion MRI

KW - Grey matter

KW - Neurite orientation dispersion and density imaging

KW - Neurodegenerative disorders

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U2 - 10.1002/hbm.24056

DO - 10.1002/hbm.24056

M3 - Article

AN - SCOPUS:85044391335

SN - 1065-9471

JO - Human Brain Mapping

JF - Human Brain Mapping

ER -

Cortical microstructure in young onset Alzheimer's disease using neurite orientation dispersion and density imaging

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Keywords

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