Cortical spreading ischemia in the absence of proximal vasospasm after aneurysmal subarachnoid hemorrhage: evidence for a dual mechanism of delayed cerebral ischemia

Anthony Strong, R. Loch Macdonald

Research output: Contribution to journalEditorialpeer-review

15 Citations (Scopus)

Abstract

There are longstanding inconsistencies in the evidence thought to link vasospasm in the major branches of the Circle of Willis with delayed cerebral ischemia and poor outcome from aneurysmal subarachnoid hemorrhage (aSAH). The demonstrations, first in the laboratory, and more recently in patients with aSAH, of cortical spreading ischemia based on an abnormal response of the cerebral microcirculation to spreading depolarization offer an additional possible mechanism for delayed ischemia. That such events can occur in the substantial absence of proximal vasospasm is compatible with this concept, but the preliminary evidence needs support from more extensive studies. Journal of Cerebral Blood Flow & Metabolism (2012) 32, 201-202; doi:10.1038/jcbfm.2011.170; published online 7 December 2011
Original languageEnglish
Pages (from-to)201 - 202
Number of pages2
JournalJournal of Cerebral Blood Flow and Metabolism
Volume32
Issue number2
DOIs
Publication statusPublished - Feb 2012

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