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Cortical thinning and accumulation of large cortical pores in the tibia reflect local structural deterioration of the femoral neck

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Cortical thinning and accumulation of large cortical pores in the tibia reflect local structural deterioration of the femoral neck. / Iori, Gianluca; Schneider, Johannes; Reisinger, Andreas; Heyer, Frans; Peralta, Laura; Wyers, Caroline; Glüer, Claus C.; van den Bergh, J. P.; Pahr, Dieter; Raum, Kay.

In: Bone, Vol. 137, 115446, 08.2020.

Research output: Contribution to journalArticle

Harvard

Iori, G, Schneider, J, Reisinger, A, Heyer, F, Peralta, L, Wyers, C, Glüer, CC, van den Bergh, JP, Pahr, D & Raum, K 2020, 'Cortical thinning and accumulation of large cortical pores in the tibia reflect local structural deterioration of the femoral neck', Bone, vol. 137, 115446. https://doi.org/10.1016/j.bone.2020.115446

APA

Iori, G., Schneider, J., Reisinger, A., Heyer, F., Peralta, L., Wyers, C., ... Raum, K. (2020). Cortical thinning and accumulation of large cortical pores in the tibia reflect local structural deterioration of the femoral neck. Bone, 137, [115446]. https://doi.org/10.1016/j.bone.2020.115446

Vancouver

Iori G, Schneider J, Reisinger A, Heyer F, Peralta L, Wyers C et al. Cortical thinning and accumulation of large cortical pores in the tibia reflect local structural deterioration of the femoral neck. Bone. 2020 Aug;137. 115446. https://doi.org/10.1016/j.bone.2020.115446

Author

Iori, Gianluca ; Schneider, Johannes ; Reisinger, Andreas ; Heyer, Frans ; Peralta, Laura ; Wyers, Caroline ; Glüer, Claus C. ; van den Bergh, J. P. ; Pahr, Dieter ; Raum, Kay. / Cortical thinning and accumulation of large cortical pores in the tibia reflect local structural deterioration of the femoral neck. In: Bone. 2020 ; Vol. 137.

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@article{3fda78ee5ca04dad98cba2ca4b44f2c1,
title = "Cortical thinning and accumulation of large cortical pores in the tibia reflect local structural deterioration of the femoral neck",
abstract = "Introduction: Cortical bone thinning and a rarefaction of the trabecular architecture represent possible causes of increased femoral neck (FN) fracture risk. Due to X-ray exposure limits, the bone microstructure is rarely measurable in the FN of subjects but can be assessed at the tibia. Here, we studied whether changes of the tibial cortical microstructure, which were previously reported to be associated with femur strength, are also associated with structural deteriorations of the femoral neck. Methods: The cortical and trabecular architectures in the FN of 19 humans were analyzed ex vivo on 3D microcomputed tomography images with 30.3 μm voxel size. Cortical thickness (Ct.Thtibia), porosity (Ct.Potibia) and pore size distribution in the tibiae of the same subjects were measured using scanning acoustic microscopy (12 μm pixel size). Femur strength during sideways falls was simulated with homogenized voxel finite element models. Results: Femur strength was associated with the total (vBMDtot; R2 = 0.23, p < 0.01) and trabecular (vBMDtrab; R2 = 0.26, p < 0.01) volumetric bone mineral density (vBMD), with the cortical thickness (Ct.ThFN; R2 = 0.29, p < 0.001) and with the trabecular bone volume fraction (Tb.BV/TVFN; R2 = 0.34, p < 0.001), separation (Tb.SpFN; R2 = 0.25, p < 0.01) and number (Tb.NFN; R2 = 0.32, p < 0.001) of the femoral neck. Moreover, smaller Ct.Thtibia was associated with smaller Ct.ThFN (R2 = 0.31, p < 0.05), lower Tb.BV/TVFN (R2 = 0.29, p < 0.05), higher Tb.SpFN (R2 = 0.33, p < 0.05) and lower Tb.NFN (R2 = 0.42, p < 0.01). A higher prevalence of pores with diameter > 100 μm in tibial cortical bone (relCt.Po100μm-tibia) indicated higher Tb.SpFN (R2 = 0.36, p < 0.01) and lower Tb.NFN (R2 = 0.45, p < 0.01). Conclusion: Bone resorption and structural decline of the femoral neck may be identified in vivo by measuring cortical bone thickness and large pores in the tibia.",
keywords = "Bone strength, Cortical bone, Finite element analysis, Hip fragility, Porosity",
author = "Gianluca Iori and Johannes Schneider and Andreas Reisinger and Frans Heyer and Laura Peralta and Caroline Wyers and Gl{\"u}er, {Claus C.} and {van den Bergh}, {J. P.} and Dieter Pahr and Kay Raum",
year = "2020",
month = "8",
doi = "10.1016/j.bone.2020.115446",
language = "English",
volume = "137",
journal = "Bone",
issn = "8756-3282",
publisher = "Elsevier Inc.",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Cortical thinning and accumulation of large cortical pores in the tibia reflect local structural deterioration of the femoral neck

AU - Iori, Gianluca

AU - Schneider, Johannes

AU - Reisinger, Andreas

AU - Heyer, Frans

AU - Peralta, Laura

AU - Wyers, Caroline

AU - Glüer, Claus C.

AU - van den Bergh, J. P.

AU - Pahr, Dieter

AU - Raum, Kay

PY - 2020/8

Y1 - 2020/8

N2 - Introduction: Cortical bone thinning and a rarefaction of the trabecular architecture represent possible causes of increased femoral neck (FN) fracture risk. Due to X-ray exposure limits, the bone microstructure is rarely measurable in the FN of subjects but can be assessed at the tibia. Here, we studied whether changes of the tibial cortical microstructure, which were previously reported to be associated with femur strength, are also associated with structural deteriorations of the femoral neck. Methods: The cortical and trabecular architectures in the FN of 19 humans were analyzed ex vivo on 3D microcomputed tomography images with 30.3 μm voxel size. Cortical thickness (Ct.Thtibia), porosity (Ct.Potibia) and pore size distribution in the tibiae of the same subjects were measured using scanning acoustic microscopy (12 μm pixel size). Femur strength during sideways falls was simulated with homogenized voxel finite element models. Results: Femur strength was associated with the total (vBMDtot; R2 = 0.23, p < 0.01) and trabecular (vBMDtrab; R2 = 0.26, p < 0.01) volumetric bone mineral density (vBMD), with the cortical thickness (Ct.ThFN; R2 = 0.29, p < 0.001) and with the trabecular bone volume fraction (Tb.BV/TVFN; R2 = 0.34, p < 0.001), separation (Tb.SpFN; R2 = 0.25, p < 0.01) and number (Tb.NFN; R2 = 0.32, p < 0.001) of the femoral neck. Moreover, smaller Ct.Thtibia was associated with smaller Ct.ThFN (R2 = 0.31, p < 0.05), lower Tb.BV/TVFN (R2 = 0.29, p < 0.05), higher Tb.SpFN (R2 = 0.33, p < 0.05) and lower Tb.NFN (R2 = 0.42, p < 0.01). A higher prevalence of pores with diameter > 100 μm in tibial cortical bone (relCt.Po100μm-tibia) indicated higher Tb.SpFN (R2 = 0.36, p < 0.01) and lower Tb.NFN (R2 = 0.45, p < 0.01). Conclusion: Bone resorption and structural decline of the femoral neck may be identified in vivo by measuring cortical bone thickness and large pores in the tibia.

AB - Introduction: Cortical bone thinning and a rarefaction of the trabecular architecture represent possible causes of increased femoral neck (FN) fracture risk. Due to X-ray exposure limits, the bone microstructure is rarely measurable in the FN of subjects but can be assessed at the tibia. Here, we studied whether changes of the tibial cortical microstructure, which were previously reported to be associated with femur strength, are also associated with structural deteriorations of the femoral neck. Methods: The cortical and trabecular architectures in the FN of 19 humans were analyzed ex vivo on 3D microcomputed tomography images with 30.3 μm voxel size. Cortical thickness (Ct.Thtibia), porosity (Ct.Potibia) and pore size distribution in the tibiae of the same subjects were measured using scanning acoustic microscopy (12 μm pixel size). Femur strength during sideways falls was simulated with homogenized voxel finite element models. Results: Femur strength was associated with the total (vBMDtot; R2 = 0.23, p < 0.01) and trabecular (vBMDtrab; R2 = 0.26, p < 0.01) volumetric bone mineral density (vBMD), with the cortical thickness (Ct.ThFN; R2 = 0.29, p < 0.001) and with the trabecular bone volume fraction (Tb.BV/TVFN; R2 = 0.34, p < 0.001), separation (Tb.SpFN; R2 = 0.25, p < 0.01) and number (Tb.NFN; R2 = 0.32, p < 0.001) of the femoral neck. Moreover, smaller Ct.Thtibia was associated with smaller Ct.ThFN (R2 = 0.31, p < 0.05), lower Tb.BV/TVFN (R2 = 0.29, p < 0.05), higher Tb.SpFN (R2 = 0.33, p < 0.05) and lower Tb.NFN (R2 = 0.42, p < 0.01). A higher prevalence of pores with diameter > 100 μm in tibial cortical bone (relCt.Po100μm-tibia) indicated higher Tb.SpFN (R2 = 0.36, p < 0.01) and lower Tb.NFN (R2 = 0.45, p < 0.01). Conclusion: Bone resorption and structural decline of the femoral neck may be identified in vivo by measuring cortical bone thickness and large pores in the tibia.

KW - Bone strength

KW - Cortical bone

KW - Finite element analysis

KW - Hip fragility

KW - Porosity

UR - http://www.scopus.com/inward/record.url?scp=85085735953&partnerID=8YFLogxK

U2 - 10.1016/j.bone.2020.115446

DO - 10.1016/j.bone.2020.115446

M3 - Article

C2 - 32450342

AN - SCOPUS:85085735953

VL - 137

JO - Bone

JF - Bone

SN - 8756-3282

M1 - 115446

ER -

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