Cortical wiring by synapse type–specific control of local protein synthesis

TY - JOUR

T1 - Cortical wiring by synapse type–specific control of local protein synthesis

AU - Bernard, Clémence

AU - Exposito-Alonso, David

AU - Selten, Martijn

AU - Sanalidou, Stella

AU - Hanusz-Godoy, Alicia

AU - Aguilera, Alfonso

AU - Hamid, Fursham

AU - Oozeer, Fazal

AU - Maeso, Patricia

AU - Allison, Leanne

AU - Russell, Matthew

AU - Fleck, Roland A.

AU - Rico, Beatriz

AU - Marín, Oscar

N1 - Publisher Copyright: © 2022 American Association for the Advancement of Science. All rights reserved.

PY - 2022/11/25

Y1 - 2022/11/25

N2 - Neurons use local protein synthesis to support their morphological complexity, which requires independent control across multiple subcellular compartments up to the level of individual synapses. We identify a signaling pathway that regulates the local synthesis of proteins required to form excitatory synapses on parvalbumin-expressing (PV+) interneurons in the mouse cerebral cortex. This process involves regulation of the TSC subunit 2 (Tsc2) by the Erb-B2 receptor tyrosine kinase 4 (ErbB4), which enables local control of messenger RNA {mRNA} translation in a cell type–specific and synapse type–specific manner. Ribosome-associated mRNA profiling reveals a molecular program of synaptic proteins downstream of ErbB4 signaling required to form excitatory inputs on PV+ interneurons. Thus, specific connections use local protein synthesis to control synapse formation in the nervous system.

AB - Neurons use local protein synthesis to support their morphological complexity, which requires independent control across multiple subcellular compartments up to the level of individual synapses. We identify a signaling pathway that regulates the local synthesis of proteins required to form excitatory synapses on parvalbumin-expressing (PV+) interneurons in the mouse cerebral cortex. This process involves regulation of the TSC subunit 2 (Tsc2) by the Erb-B2 receptor tyrosine kinase 4 (ErbB4), which enables local control of messenger RNA {mRNA} translation in a cell type–specific and synapse type–specific manner. Ribosome-associated mRNA profiling reveals a molecular program of synaptic proteins downstream of ErbB4 signaling required to form excitatory inputs on PV+ interneurons. Thus, specific connections use local protein synthesis to control synapse formation in the nervous system.

UR - https://www.scopus.com/pages/publications/85142647074

U2 - 10.1126/science.abm7466

DO - 10.1126/science.abm7466

M3 - Article

C2 - 36423280

AN - SCOPUS:85142647074

SN - 0036-8075

VL - 378

JO - Science

JF - Science

IS - 6622

ER -