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Cortisol stress response in psychosis from the high-risk to the chronic stage: a systematic review

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Cortisol stress response in psychosis from the high-risk to the chronic stage : a systematic review. / Dauvermann, M R; Donohoe, G.

In: Irish Journal of Psychological Medicine, Vol. 36, No. 4, 12.2019, p. 305-315.

Research output: Contribution to journalArticlepeer-review

Harvard

Dauvermann, MR & Donohoe, G 2019, 'Cortisol stress response in psychosis from the high-risk to the chronic stage: a systematic review', Irish Journal of Psychological Medicine, vol. 36, no. 4, pp. 305-315. https://doi.org/10.1017/ipm.2019.27

APA

Dauvermann, M. R., & Donohoe, G. (2019). Cortisol stress response in psychosis from the high-risk to the chronic stage: a systematic review. Irish Journal of Psychological Medicine, 36(4), 305-315. https://doi.org/10.1017/ipm.2019.27

Vancouver

Dauvermann MR, Donohoe G. Cortisol stress response in psychosis from the high-risk to the chronic stage: a systematic review. Irish Journal of Psychological Medicine. 2019 Dec;36(4):305-315. https://doi.org/10.1017/ipm.2019.27

Author

Dauvermann, M R ; Donohoe, G. / Cortisol stress response in psychosis from the high-risk to the chronic stage : a systematic review. In: Irish Journal of Psychological Medicine. 2019 ; Vol. 36, No. 4. pp. 305-315.

Bibtex Download

@article{23b4fe5753344ac2b444e40f623ad209,
title = "Cortisol stress response in psychosis from the high-risk to the chronic stage: a systematic review",
abstract = "OBJECTIVES: We review studies of whether cortisol levels following psychosocial stress exposure differ between patients with psychosis and healthy control subjects.METHODS: Original research published between 1993 and February 2019 was included in the literature search. Studies that used experimentally induced psychosocial stress and reported stress response measures of plasma or saliva cortisol levels in patients at any stage of illness (i.e. high risk, first episode and chronic phase) were included.RESULTS: A total of 17 studies were included. Although there was evidence of inconsistencies in measures, we observed moderate evidence of an association with stress-induced cortisol blunting response across studies.CONCLUSIONS: This review highlights recent evidence of blunting of cortisol response following experimentally induced psychosocial stress. While there was some evidence of this blunted response across illness types and stages, the strongest evidence was observed for those with chronic schizophrenia. Due to the low number of studies, in particular in bipolar disorder, much work is still needed to accurately characterise the biological effects of stress in psychosis.",
keywords = "Bipolar Disorder/blood, Chronic Disease, Female, Humans, Hydrocortisone/blood, Hypothalamo-Hypophyseal System/physiology, Male, Pituitary-Adrenal System/physiology, Psychotic Disorders/metabolism, Risk, Saliva/metabolism, Schizophrenia/blood, Stress, Physiological/physiology, Stress, Psychological/metabolism",
author = "Dauvermann, {M R} and G Donohoe",
year = "2019",
month = dec,
doi = "10.1017/ipm.2019.27",
language = "English",
volume = "36",
pages = "305--315",
journal = "Irish Journal of Psychological Medicine",
issn = "0790-9667",
publisher = "MedMedia Ltd",
number = "4",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Cortisol stress response in psychosis from the high-risk to the chronic stage

T2 - a systematic review

AU - Dauvermann, M R

AU - Donohoe, G

PY - 2019/12

Y1 - 2019/12

N2 - OBJECTIVES: We review studies of whether cortisol levels following psychosocial stress exposure differ between patients with psychosis and healthy control subjects.METHODS: Original research published between 1993 and February 2019 was included in the literature search. Studies that used experimentally induced psychosocial stress and reported stress response measures of plasma or saliva cortisol levels in patients at any stage of illness (i.e. high risk, first episode and chronic phase) were included.RESULTS: A total of 17 studies were included. Although there was evidence of inconsistencies in measures, we observed moderate evidence of an association with stress-induced cortisol blunting response across studies.CONCLUSIONS: This review highlights recent evidence of blunting of cortisol response following experimentally induced psychosocial stress. While there was some evidence of this blunted response across illness types and stages, the strongest evidence was observed for those with chronic schizophrenia. Due to the low number of studies, in particular in bipolar disorder, much work is still needed to accurately characterise the biological effects of stress in psychosis.

AB - OBJECTIVES: We review studies of whether cortisol levels following psychosocial stress exposure differ between patients with psychosis and healthy control subjects.METHODS: Original research published between 1993 and February 2019 was included in the literature search. Studies that used experimentally induced psychosocial stress and reported stress response measures of plasma or saliva cortisol levels in patients at any stage of illness (i.e. high risk, first episode and chronic phase) were included.RESULTS: A total of 17 studies were included. Although there was evidence of inconsistencies in measures, we observed moderate evidence of an association with stress-induced cortisol blunting response across studies.CONCLUSIONS: This review highlights recent evidence of blunting of cortisol response following experimentally induced psychosocial stress. While there was some evidence of this blunted response across illness types and stages, the strongest evidence was observed for those with chronic schizophrenia. Due to the low number of studies, in particular in bipolar disorder, much work is still needed to accurately characterise the biological effects of stress in psychosis.

KW - Bipolar Disorder/blood

KW - Chronic Disease

KW - Female

KW - Humans

KW - Hydrocortisone/blood

KW - Hypothalamo-Hypophyseal System/physiology

KW - Male

KW - Pituitary-Adrenal System/physiology

KW - Psychotic Disorders/metabolism

KW - Risk

KW - Saliva/metabolism

KW - Schizophrenia/blood

KW - Stress, Physiological/physiology

KW - Stress, Psychological/metabolism

U2 - 10.1017/ipm.2019.27

DO - 10.1017/ipm.2019.27

M3 - Article

C2 - 31317845

VL - 36

SP - 305

EP - 315

JO - Irish Journal of Psychological Medicine

JF - Irish Journal of Psychological Medicine

SN - 0790-9667

IS - 4

ER -

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