Cost-effectiveness of acceptance and commitment therapy for people living with motor neuron disease, and their health-related quality of life

Anju Keetharuth, Rebecca Gould, Christopher McDermott, Benjamin Thompson, Charlotte Rawlinson, Mike Bradburn, Matt Bursnall, Pavithra Kumar, Emily Turton, Paul Tappenden, David White, Robert Howard, Marc Serfaty, Lance McCracken, Christopher Graham, Ammar Al-Chalabi, Laura Goldstein, Vanessa Lawrence, Cindy Cooper, Tracy YoungCOMMEND Collaboration Group

Research output: Contribution to journalArticlepeer-review


Background: Given the degenerative nature of the condition, people living with motor neuron disease (MND) experience high levels of psychological distress. The purpose of this research was to investigate the cost-effectiveness of acceptance and commitment therapy (ACT), adapted for the specific needs of this population, for improving quality of life. Methods: A trial-based cost–utility analysis over a 9-month period was conducted comparing ACT plus usual care (n = 97) versus usual care alone (n = 94) from the perspective of the National Health Service. In the primary analysis, quality-adjusted life years (QALYs) were computed using health utilities generated from the EQ-5D-5L questionnaire. Sensitivity analyses and subgroup analyses were also carried out. Results: Difference in costs was statistically significant between the two arms, driven mainly by the intervention costs. Effects measured by EQ-5D-5L were not statistically significantly different between the two arms. The incremental cost-effectiveness was above the £20,000 to £30,000 per QALY gained threshold used in the UK. However, the difference in effects was statistically significant when measured by the McGill Quality of Life-Revised (MQOL-R) questionnaire. The intervention was cost-effective in a subgroup experiencing medium deterioration in motor neuron symptoms. Conclusions: Despite the intervention being cost-ineffective in the primary analysis, the significant difference in the effects measured by MQOL-R, the low costs of the intervention, the results in the subgroup analysis, and the fact that ACT was shown to improve the quality of life for people living with MND, suggest that ACT could be incorporated into MND clinical services.

Original languageEnglish
JournalEuropean Journal of Neurology
Publication statusPublished - 25 Apr 2024


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