Could muscle deformity in children with spastic cerebral palsy be related to an impairment of muscle growth and altered adaptation?

Martin Gough*, Adam Shortland

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

95 Citations (Scopus)

Abstract

Skeletal muscle deformity is common in children with spastic cerebral palsy (CP), but the underlying mechanisms are unclear. This review explores some possible factors which may influence the development of muscle deformity in CP. Normal muscle function and growth appear to depend on the interaction of neuronal, endocrinal, nutritional, and mechanical factors, and also on the development of an appropriate balance between muscle protein synthesis and degradation, and between the development of contractile and non-contractile components. In this context, the changes seen in muscle in children with CP are reviewed and discussed. It is suggested that the development of muscle deformity in children with CP may be related to a multifactorial impairment of muscle growth, on which adaptation of the extracellular matrix due to altered loading may be imposed.

Original languageEnglish
Pages (from-to)495-499
Number of pages5
JournalDevelopmental Medicine and Child Neurology
Volume54
Issue number6
DOIs
Publication statusPublished - Jun 2012

Keywords

  • MYOFIBRILLAR PROTEIN-SYNTHESIS
  • HUMAN SKELETAL-MUSCLE
  • SPINAL-CORD-INJURY
  • RAT SOLEUS MUSCLE
  • TRANSLATION INITIATION
  • EXTRACELLULAR-MATRIX
  • GASTROCNEMIUS-MUSCLE
  • BRACHIAL-PLEXUS
  • VASTUS LATERALIS
  • PASSIVE STRETCH

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