Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking.

Research output: Contribution to journalReview articlepeer-review

29 Citations (Scopus)
118 Downloads (Pure)

Abstract

Microscopy and medical imaging are related in their exploitation of electromagnetic waves, but were developed to satisfy differing needs, namely to observe small objects or to look inside subjects/objects, respectively. Together, these techniques can help elucidate complex biological processes and better understand health and disease. A current major challenge is to delineate mechanisms governing cell migration and tissue invasion in organismal development, the immune system and in human diseases such as cancer where the spatiotemporal tracking of small cell numbers in live animal models is extremely challenging.
Multi-modal multi-scale in vivo cell tracking integrates medical and optical imaging. Fuelled by basic research in cancer biology and cell-based therapeutics, it has been enabled by technological advances providing enhanced resolution, sensitivity and multiplexing capabilities. Here, we review which imaging modalities have been successfully used for in vivo cell tracking and how this challenging task has benefitted from combining macroscopic with microscopic techniques.
Original languageEnglish
Pages (from-to)40-50
Number of pages11
JournalThe international journal of biochemistry & cell biology
Volume102
Early online date28 Jun 2018
DOIs
Publication statusPublished - Sept 2018

Keywords

  • Animals
  • Cell Tracking/methods
  • Diagnostic Imaging
  • Humans
  • Neoplasms/diagnostic imaging
  • Optical Imaging

Fingerprint

Dive into the research topics of 'Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking.'. Together they form a unique fingerprint.

Cite this