Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking.

Alessia Volpe; Ewelina Kurtys; Gilbert O Fruhwirth

doi:10.1016/j.biocel.2018.06.008

Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking.

Alessia Volpe, Ewelina Kurtys, Gilbert O Fruhwirth

Imaging Chemistry & Biology

Research output: Contribution to journal › Review article › peer-review

30 Citations (Scopus)

138 Downloads (Pure)

Abstract

Microscopy and medical imaging are related in their exploitation of electromagnetic waves, but were developed to satisfy differing needs, namely to observe small objects or to look inside subjects/objects, respectively. Together, these techniques can help elucidate complex biological processes and better understand health and disease. A current major challenge is to delineate mechanisms governing cell migration and tissue invasion in organismal development, the immune system and in human diseases such as cancer where the spatiotemporal tracking of small cell numbers in live animal models is extremely challenging.
Multi-modal multi-scale in vivo cell tracking integrates medical and optical imaging. Fuelled by basic research in cancer biology and cell-based therapeutics, it has been enabled by technological advances providing enhanced resolution, sensitivity and multiplexing capabilities. Here, we review which imaging modalities have been successfully used for in vivo cell tracking and how this challenging task has benefitted from combining macroscopic with microscopic techniques.

Original language	English
Pages (from-to)	40-50
Number of pages	11
Journal	The international journal of biochemistry & cell biology
Volume	102
Early online date	28 Jun 2018
DOIs	https://doi.org/10.1016/j.biocel.2018.06.008
Publication status	Published - Sept 2018

Keywords

Animals
Cell Tracking/methods
Diagnostic Imaging
Humans
Neoplasms/diagnostic imaging
Optical Imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biocel.2018.06.008

Cousins at work How_VOLPE_Accepted26June2018_GREEN AAM (CC BY-NC-ND)
© <2018> This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
Accepted author manuscript, 2.55 MBLicence: CC BY-NC-ND

Cite this

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title = "Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking.",

abstract = "Microscopy and medical imaging are related in their exploitation of electromagnetic waves, but were developed to satisfy differing needs, namely to observe small objects or to look inside subjects/objects, respectively. Together, these techniques can help elucidate complex biological processes and better understand health and disease. A current major challenge is to delineate mechanisms governing cell migration and tissue invasion in organismal development, the immune system and in human diseases such as cancer where the spatiotemporal tracking of small cell numbers in live animal models is extremely challenging.Multi-modal multi-scale in vivo cell tracking integrates medical and optical imaging. Fuelled by basic research in cancer biology and cell-based therapeutics, it has been enabled by technological advances providing enhanced resolution, sensitivity and multiplexing capabilities. Here, we review which imaging modalities have been successfully used for in vivo cell tracking and how this challenging task has benefitted from combining macroscopic with microscopic techniques. ",

keywords = "Animals, Cell Tracking/methods, Diagnostic Imaging, Humans, Neoplasms/diagnostic imaging, Optical Imaging",

author = "Alessia Volpe and Ewelina Kurtys and Fruhwirth, {Gilbert O}",

note = "Copyright {\textcopyright} 2018. Published by Elsevier Ltd.",

year = "2018",

month = sep,

doi = "10.1016/j.biocel.2018.06.008",

language = "English",

volume = "102",

pages = "40--50",

journal = "The international journal of biochemistry & cell biology",

issn = "1357-2725",

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TY - JOUR

T1 - Cousins at work

T2 - How combining medical with optical imaging enhances in vivo cell tracking.

AU - Volpe, Alessia

AU - Kurtys, Ewelina

AU - Fruhwirth, Gilbert O

PY - 2018/9

Y1 - 2018/9

N2 - Microscopy and medical imaging are related in their exploitation of electromagnetic waves, but were developed to satisfy differing needs, namely to observe small objects or to look inside subjects/objects, respectively. Together, these techniques can help elucidate complex biological processes and better understand health and disease. A current major challenge is to delineate mechanisms governing cell migration and tissue invasion in organismal development, the immune system and in human diseases such as cancer where the spatiotemporal tracking of small cell numbers in live animal models is extremely challenging.Multi-modal multi-scale in vivo cell tracking integrates medical and optical imaging. Fuelled by basic research in cancer biology and cell-based therapeutics, it has been enabled by technological advances providing enhanced resolution, sensitivity and multiplexing capabilities. Here, we review which imaging modalities have been successfully used for in vivo cell tracking and how this challenging task has benefitted from combining macroscopic with microscopic techniques.

AB - Microscopy and medical imaging are related in their exploitation of electromagnetic waves, but were developed to satisfy differing needs, namely to observe small objects or to look inside subjects/objects, respectively. Together, these techniques can help elucidate complex biological processes and better understand health and disease. A current major challenge is to delineate mechanisms governing cell migration and tissue invasion in organismal development, the immune system and in human diseases such as cancer where the spatiotemporal tracking of small cell numbers in live animal models is extremely challenging.Multi-modal multi-scale in vivo cell tracking integrates medical and optical imaging. Fuelled by basic research in cancer biology and cell-based therapeutics, it has been enabled by technological advances providing enhanced resolution, sensitivity and multiplexing capabilities. Here, we review which imaging modalities have been successfully used for in vivo cell tracking and how this challenging task has benefitted from combining macroscopic with microscopic techniques.

KW - Animals

KW - Cell Tracking/methods

KW - Diagnostic Imaging

KW - Humans

KW - Neoplasms/diagnostic imaging

KW - Optical Imaging

U2 - 10.1016/j.biocel.2018.06.008

DO - 10.1016/j.biocel.2018.06.008

M3 - Review article

C2 - 29960079

SN - 1357-2725

VL - 102

SP - 40

EP - 50

JO - The international journal of biochemistry & cell biology

JF - The international journal of biochemistry & cell biology

ER -

Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking.

Abstract

Keywords

UN SDGs

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