Covid-19 and Parkinson's disease: Acute clinical implications, long-COVID and post-COVID-19 parkinsonism

TY - CHAP

T1 - Covid-19 and Parkinson's disease

T2 - Acute clinical implications, long-COVID and post-COVID-19 parkinsonism

AU - Leta, Valentina

AU - Boura, Iro

AU - van Wamelen, Daniel J.

AU - Rodriguez-Violante, Mayela

AU - Antonini, Angelo

AU - Chaudhuri, Kallol Ray

N1 - Publisher Copyright: © 2022 Elsevier Inc.

PY - 2022/1

Y1 - 2022/1

N2 - The Coronavirus Disease 2019 (Covid-19), caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has led to unprecedented challenges for the delivery of healthcare and has had a clear impact on people with chronic neurological conditions such as Parkinson's disease (PD). Acute worsening of motor and non-motor symptoms and long-term sequalae have been described during and after SARS-CoV-2 infections in people with Parkinson's (PwP), which are likely to be multifactorial in their origin. On the one hand, it is likely that worsening of symptoms has been related to the viral infection itself, whereas social restrictions imposed over the course of the Covid-19 pandemic might also have had such an effect. Twenty cases of post-Covid-19 para-infectious or post-infectious parkinsonism have been described so far where a variety of pathophysiological mechanisms seem to be involved; however, a Covid-19-induced wave of post-viral parkinsonism seems rather unlikely at the moment. Here, we describe the interaction between SARS-CoV-2 and PD in the short- and long-term and summarize the clinical features of post-Covid-19 cases of parkinsonism observed so far.

AB - The Coronavirus Disease 2019 (Covid-19), caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has led to unprecedented challenges for the delivery of healthcare and has had a clear impact on people with chronic neurological conditions such as Parkinson's disease (PD). Acute worsening of motor and non-motor symptoms and long-term sequalae have been described during and after SARS-CoV-2 infections in people with Parkinson's (PwP), which are likely to be multifactorial in their origin. On the one hand, it is likely that worsening of symptoms has been related to the viral infection itself, whereas social restrictions imposed over the course of the Covid-19 pandemic might also have had such an effect. Twenty cases of post-Covid-19 para-infectious or post-infectious parkinsonism have been described so far where a variety of pathophysiological mechanisms seem to be involved; however, a Covid-19-induced wave of post-viral parkinsonism seems rather unlikely at the moment. Here, we describe the interaction between SARS-CoV-2 and PD in the short- and long-term and summarize the clinical features of post-Covid-19 cases of parkinsonism observed so far.

KW - Covid-19

KW - Long-COVID

KW - Motor symptoms

KW - Non-motor symptoms

KW - Parkinson's disease

KW - Parkinsonism

KW - SARS-CoV-2

UR - http://www.scopus.com/inward/record.url?scp=85135513657&partnerID=8YFLogxK

U2 - 10.1016/bs.irn.2022.04.004

DO - 10.1016/bs.irn.2022.04.004

M3 - Chapter

AN - SCOPUS:85135513657

SN - 9780323991735

T3 - International Review of Neurobiology

SP - 63

EP - 89

BT - Covid-19 and Parkinsonism

A2 - Chaudhuri, K Ray

A2 - Rodríguez-Violante, Mayela

A2 - Antonini, Angelo

A2 - Boura, Iro

A2 - Boura, Iro

PB - ACADEMIC PRESS INC

ER -