COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease - 3rd CIAO AOP Design Workshop

CIAO – Modelling the Pathogenesis of COVID 19 using the Adverse Outcome Pathway Framework; Laure-Alix Clerbaux; Núria Amigó; Maria João Amorim; Anna Bal-Price; Sofia Batista Leite; Anna Beronius; Gillina F G Bezemer; Ann-Charlotte Bostroem; Annamaria Carusi; Sandra Coecke; Rachel Concha; Evangelos P Daskalopoulos; Francesca De Bernardi; Eizleayne Edrosa; Steve W Edwards; Julija Filipovska; Natàlia Garcia-Reyero; Felicity N E Gavins; Sabina Halappanavar; Alan J Hargreaves; Helena T Hogberg; Mylène T Huynh; Daniel Jacobson; Jonathan Josephs-Spaulding; Young Jun Kim; Hyun Joon Kong; Catharine E Krebs; Ann Lam; Brigitte Landesmann; Adrienne Layton; Yong Oh Lee; Donna S Macmillan; Alberto Mantovani; Luigi Margiotta-Casaluci; Marvin Martens; Rosalinde Masereeuw; Sally A Mayasich; Liang Merlin Mei; Holly Mortensen; Amalia Munoz Pineiro; Penny Nymark; Elan Ohayon; Joshi Ojasi; Alicia Paini; Nikolaos Parissis; Surat Parvatam; Francesca Pistollato; Magdalini Sachana; Jorid Birkelund Sørli; Kristie M Sullivan

doi:10.14573/altex.2112161

COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease - 3rd CIAO AOP Design Workshop

CIAO – Modelling the Pathogenesis of COVID 19 using the Adverse Outcome Pathway Framework, Laure-Alix Clerbaux, Núria Amigó, Maria João Amorim, Anna Bal-Price, Sofia Batista Leite, Anna Beronius, Gillina F G Bezemer, Ann-Charlotte Bostroem, Annamaria Carusi, Sandra Coecke, Rachel Concha, Evangelos P Daskalopoulos, Francesca De Bernardi, Eizleayne Edrosa, Steve W Edwards, Julija Filipovska, Natàlia Garcia-Reyero, Felicity N E Gavins, Sabina HalappanavarAlan J Hargreaves, Helena T Hogberg, Mylène T Huynh, Daniel Jacobson, Jonathan Josephs-Spaulding, Young Jun Kim, Hyun Joon Kong, Catharine E Krebs, Ann Lam, Brigitte Landesmann, Adrienne Layton, Yong Oh Lee, Donna S Macmillan, Alberto Mantovani, Luigi Margiotta-Casaluci, Marvin Martens, Rosalinde Masereeuw, Sally A Mayasich, Liang Merlin Mei, Holly Mortensen, Amalia Munoz Pineiro, Penny Nymark, Elan Ohayon, Joshi Ojasi, Alicia Paini, Nikolaos Parissis, Surat Parvatam, Francesca Pistollato, Magdalini Sachana, Jorid Birkelund Sørli, Kristie M Sullivan

Analytical, Environmental & Forensic Sciences

Research output: Contribution to journal › Editorial › peer-review

14 Citations (Scopus)

Abstract

On April 28-29, 2021, 50 scientists from different fields of expertise met for the 3rd online CIAO workshop. The CIAO project “Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway (AOP) framework” aims at building a holistic assembly of the available scientific knowledge on COVID-19 using the AOP framework. An individual AOP depicts the disease progression from the initial contact with the SARS-CoV-2 virus through biological key events (KE) toward an adverse outcome such as respiratory distress, anosmia or multiorgan failure. Assembling the individual AOPs into a network highlights shared KEs as central biological nodes involved in multiple outcomes observed in COVID-19 patients. During the workshop, the KEs and AOPs established so far by the CIAO members were presented and positioned on a timeline of the disease course. Modulating factors influencing the progression and severity of the disease were also addressed as well as factors beyond purely biological phenomena. CIAO relies on an interdisciplinary crowdsourcing effort, therefore, approaches to expand the CIAO network by widening the crowd and reaching stakeholders were also discussed. To conclude the workshop, it was decided that the AOPs/KEs will be further consolidated, integrating virus variants and long COVID when relevant, while an outreach campaign will be launched to broaden the CIAO scientific crowd.

Original language	English
Pages (from-to)	322–335
Number of pages	14
Journal	ALTEX
Volume	39
Issue number	2
DOIs	https://doi.org/10.14573/altex.2112161
Publication status	Published - 2022

Keywords

Adverse Outcome Pathways
COVID-19/complications
Humans
SARS-CoV-2

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10.14573/altex.2112161

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CIAO – Modelling the Pathogenesis of COVID 19 using the Adverse Outcome Pathway Framework, Clerbaux, L.-A., Amigó, N., Amorim, M. J., Bal-Price, A., Batista Leite, S., Beronius, A., Bezemer, G. F. G., Bostroem, A.-C., Carusi, A., Coecke, S., Concha, R., Daskalopoulos, E. P., De Bernardi, F., Edrosa, E., Edwards, S. W., Filipovska, J., Garcia-Reyero, N., Gavins, F. N. E., ... Sullivan, K. M. (2022). COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease - 3rd CIAO AOP Design Workshop. ALTEX, 39(2), 322–335. https://doi.org/10.14573/altex.2112161

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title = "COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease - 3rd CIAO AOP Design Workshop",

abstract = "On April 28-29, 2021, 50 scientists from different fields of expertise met for the 3rd online CIAO workshop. The CIAO project “Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway (AOP) framework” aims at building a holistic assembly of the available scientific knowledge on COVID-19 using the AOP framework. An individual AOP depicts the disease progression from the initial contact with the SARS-CoV-2 virus through biological key events (KE) toward an adverse outcome such as respiratory distress, anosmia or multiorgan failure. Assembling the individual AOPs into a network highlights shared KEs as central biological nodes involved in multiple outcomes observed in COVID-19 patients. During the workshop, the KEs and AOPs established so far by the CIAO members were presented and positioned on a timeline of the disease course. Modulating factors influencing the progression and severity of the disease were also addressed as well as factors beyond purely biological phenomena. CIAO relies on an interdisciplinary crowdsourcing effort, therefore, approaches to expand the CIAO network by widening the crowd and reaching stakeholders were also discussed. To conclude the workshop, it was decided that the AOPs/KEs will be further consolidated, integrating virus variants and long COVID when relevant, while an outreach campaign will be launched to broaden the CIAO scientific crowd.",

keywords = "Adverse Outcome Pathways, COVID-19/complications, Humans, SARS-CoV-2",

author = "{CIAO – Modelling the Pathogenesis of COVID 19 using the Adverse Outcome Pathway Framework} and Laure-Alix Clerbaux and N{\'u}ria Amig{\'o} and Amorim, {Maria Jo{\~a}o} and Anna Bal-Price and {Batista Leite}, Sofia and Anna Beronius and Bezemer, {Gillina F G} and Ann-Charlotte Bostroem and Annamaria Carusi and Sandra Coecke and Rachel Concha and Daskalopoulos, {Evangelos P} and {De Bernardi}, Francesca and Eizleayne Edrosa and Edwards, {Steve W} and Julija Filipovska and Nat{\`a}lia Garcia-Reyero and Gavins, {Felicity N E} and Sabina Halappanavar and Hargreaves, {Alan J} and Hogberg, {Helena T} and Huynh, {Myl{\`e}ne T} and Daniel Jacobson and Jonathan Josephs-Spaulding and Kim, {Young Jun} and Kong, {Hyun Joon} and Krebs, {Catharine E} and Ann Lam and Brigitte Landesmann and Adrienne Layton and Lee, {Yong Oh} and Macmillan, {Donna S} and Alberto Mantovani and Luigi Margiotta-Casaluci and Marvin Martens and Rosalinde Masereeuw and Mayasich, {Sally A} and Mei, {Liang Merlin} and Holly Mortensen and {Munoz Pineiro}, Amalia and Penny Nymark and Elan Ohayon and Joshi Ojasi and Alicia Paini and Nikolaos Parissis and Surat Parvatam and Francesca Pistollato and Magdalini Sachana and S{\o}rli, {Jorid Birkelund} and Sullivan, {Kristie M}",

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language = "English",

volume = "39",

pages = "322–335",

journal = "ALTEX",

issn = "1868-596X",

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number = "2",

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CIAO – Modelling the Pathogenesis of COVID 19 using the Adverse Outcome Pathway Framework, Clerbaux, L-A, Amigó, N, Amorim, MJ, Bal-Price, A, Batista Leite, S, Beronius, A, Bezemer, GFG, Bostroem, A-C, Carusi, A, Coecke, S, Concha, R, Daskalopoulos, EP, De Bernardi, F, Edrosa, E, Edwards, SW, Filipovska, J, Garcia-Reyero, N, Gavins, FNE, Halappanavar, S, Hargreaves, AJ, Hogberg, HT, Huynh, MT, Jacobson, D, Josephs-Spaulding, J, Kim, YJ, Kong, HJ, Krebs, CE, Lam, A, Landesmann, B, Layton, A, Lee, YO, Macmillan, DS, Mantovani, A, Margiotta-Casaluci, L, Martens, M, Masereeuw, R, Mayasich, SA, Mei, LM, Mortensen, H, Munoz Pineiro, A, Nymark, P, Ohayon, E, Ojasi, J, Paini, A, Parissis, N, Parvatam, S, Pistollato, F, Sachana, M, Sørli, JB & Sullivan, KM 2022, 'COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease - 3rd CIAO AOP Design Workshop', ALTEX, vol. 39, no. 2, pp. 322–335. https://doi.org/10.14573/altex.2112161

COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease - 3rd CIAO AOP Design Workshop. / CIAO – Modelling the Pathogenesis of COVID 19 using the Adverse Outcome Pathway Framework; Clerbaux, Laure-Alix; Amigó, Núria et al.
In: ALTEX, Vol. 39, No. 2, 2022, p. 322–335.

Research output: Contribution to journal › Editorial › peer-review

TY - JOUR

T1 - COVID-19 through Adverse Outcome Pathways

T2 - Building networks to better understand the disease - 3rd CIAO AOP Design Workshop

AU - CIAO – Modelling the Pathogenesis of COVID 19 using the Adverse Outcome Pathway Framework

AU - Clerbaux, Laure-Alix

AU - Amigó, Núria

AU - Amorim, Maria João

AU - Bal-Price, Anna

AU - Batista Leite, Sofia

AU - Beronius, Anna

AU - Bezemer, Gillina F G

AU - Bostroem, Ann-Charlotte

AU - Carusi, Annamaria

AU - Coecke, Sandra

AU - Concha, Rachel

AU - Daskalopoulos, Evangelos P

AU - De Bernardi, Francesca

AU - Edrosa, Eizleayne

AU - Edwards, Steve W

AU - Filipovska, Julija

AU - Garcia-Reyero, Natàlia

AU - Gavins, Felicity N E

AU - Halappanavar, Sabina

AU - Hargreaves, Alan J

AU - Hogberg, Helena T

AU - Huynh, Mylène T

AU - Jacobson, Daniel

AU - Josephs-Spaulding, Jonathan

AU - Kim, Young Jun

AU - Kong, Hyun Joon

AU - Krebs, Catharine E

AU - Lam, Ann

AU - Landesmann, Brigitte

AU - Layton, Adrienne

AU - Lee, Yong Oh

AU - Macmillan, Donna S

AU - Mantovani, Alberto

AU - Margiotta-Casaluci, Luigi

AU - Martens, Marvin

AU - Masereeuw, Rosalinde

AU - Mayasich, Sally A

AU - Mei, Liang Merlin

AU - Mortensen, Holly

AU - Munoz Pineiro, Amalia

AU - Nymark, Penny

AU - Ohayon, Elan

AU - Ojasi, Joshi

AU - Paini, Alicia

AU - Parissis, Nikolaos

AU - Parvatam, Surat

AU - Pistollato, Francesca

AU - Sachana, Magdalini

AU - Sørli, Jorid Birkelund

AU - Sullivan, Kristie M

PY - 2022

Y1 - 2022

N2 - On April 28-29, 2021, 50 scientists from different fields of expertise met for the 3rd online CIAO workshop. The CIAO project “Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway (AOP) framework” aims at building a holistic assembly of the available scientific knowledge on COVID-19 using the AOP framework. An individual AOP depicts the disease progression from the initial contact with the SARS-CoV-2 virus through biological key events (KE) toward an adverse outcome such as respiratory distress, anosmia or multiorgan failure. Assembling the individual AOPs into a network highlights shared KEs as central biological nodes involved in multiple outcomes observed in COVID-19 patients. During the workshop, the KEs and AOPs established so far by the CIAO members were presented and positioned on a timeline of the disease course. Modulating factors influencing the progression and severity of the disease were also addressed as well as factors beyond purely biological phenomena. CIAO relies on an interdisciplinary crowdsourcing effort, therefore, approaches to expand the CIAO network by widening the crowd and reaching stakeholders were also discussed. To conclude the workshop, it was decided that the AOPs/KEs will be further consolidated, integrating virus variants and long COVID when relevant, while an outreach campaign will be launched to broaden the CIAO scientific crowd.

AB - On April 28-29, 2021, 50 scientists from different fields of expertise met for the 3rd online CIAO workshop. The CIAO project “Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway (AOP) framework” aims at building a holistic assembly of the available scientific knowledge on COVID-19 using the AOP framework. An individual AOP depicts the disease progression from the initial contact with the SARS-CoV-2 virus through biological key events (KE) toward an adverse outcome such as respiratory distress, anosmia or multiorgan failure. Assembling the individual AOPs into a network highlights shared KEs as central biological nodes involved in multiple outcomes observed in COVID-19 patients. During the workshop, the KEs and AOPs established so far by the CIAO members were presented and positioned on a timeline of the disease course. Modulating factors influencing the progression and severity of the disease were also addressed as well as factors beyond purely biological phenomena. CIAO relies on an interdisciplinary crowdsourcing effort, therefore, approaches to expand the CIAO network by widening the crowd and reaching stakeholders were also discussed. To conclude the workshop, it was decided that the AOPs/KEs will be further consolidated, integrating virus variants and long COVID when relevant, while an outreach campaign will be launched to broaden the CIAO scientific crowd.

KW - Adverse Outcome Pathways

KW - COVID-19/complications

KW - Humans

KW - SARS-CoV-2

UR - http://www.scopus.com/inward/record.url?scp=85128487716&partnerID=8YFLogxK

U2 - 10.14573/altex.2112161

DO - 10.14573/altex.2112161

M3 - Editorial

C2 - 35032963

SN - 1868-596X

VL - 39

SP - 322

EP - 335

JO - ALTEX

JF - ALTEX

IS - 2

ER -

COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease - 3rd CIAO AOP Design Workshop

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