COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease - 3rd CIAO AOP Design Workshop

CIAO – Modelling the Pathogenesis of COVID 19 using the Adverse Outcome Pathway Framework, Laure-Alix Clerbaux, Núria Amigó, Maria João Amorim, Anna Bal-Price, Sofia Batista Leite, Anna Beronius, Gillina F G Bezemer, Ann-Charlotte Bostroem, Annamaria Carusi, Sandra Coecke, Rachel Concha, Evangelos P Daskalopoulos, Francesca De Bernardi, Eizleayne Edrosa, Steve W Edwards, Julija Filipovska, Natàlia Garcia-Reyero, Felicity N E Gavins, Sabina HalappanavarAlan J Hargreaves, Helena T Hogberg, Mylène T Huynh, Daniel Jacobson, Jonathan Josephs-Spaulding, Young Jun Kim, Hyun Joon Kong, Catharine E Krebs, Ann Lam, Brigitte Landesmann, Adrienne Layton, Yong Oh Lee, Donna S Macmillan, Alberto Mantovani, Luigi Margiotta-Casaluci, Marvin Martens, Rosalinde Masereeuw, Sally A Mayasich, Liang Merlin Mei, Holly Mortensen, Amalia Munoz Pineiro, Penny Nymark, Elan Ohayon, Joshi Ojasi, Alicia Paini, Nikolaos Parissis, Surat Parvatam, Francesca Pistollato, Magdalini Sachana, Jorid Birkelund Sørli, Kristie M Sullivan

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11 Citations (Scopus)


On April 28-29, 2021, 50 scientists from different fields of expertise met for the 3rd online CIAO workshop. The CIAO project “Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway (AOP) framework” aims at building a holistic assembly of the available scientific knowledge on COVID-19 using the AOP framework. An individual AOP depicts the disease progression from the initial contact with the SARS-CoV-2 virus through biological key events (KE) toward an adverse outcome such as respiratory distress, anosmia or multiorgan failure. Assembling the individual AOPs into a network highlights shared KEs as central biological nodes involved in multiple outcomes observed in COVID-19 patients. During the workshop, the KEs and AOPs established so far by the CIAO members were presented and posi­tioned on a timeline of the disease course. Modulating factors influencing the progression and severity of the disease were also addressed as well as factors beyond purely biological phenomena. CIAO relies on an interdisciplinary crowd­sourcing effort, therefore, approaches to expand the CIAO network by widening the crowd and reaching stakeholders were also discussed. To conclude the workshop, it was decided that the AOPs/KEs will be further consolidated, inte­grating virus variants and long COVID when relevant, while an outreach campaign will be launched to broaden the CIAO scientific crowd.

Original languageEnglish
Pages (from-to)322–335
Number of pages14
Issue number2
Publication statusPublished - 2022


  • Adverse Outcome Pathways
  • COVID-19/complications
  • Humans
  • SARS-CoV-2


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