Creatinine: From physiology to clinical application

Kianoush Kashani; Mitchell H. Rosner; Marlies Ostermann

doi:10.1016/j.ejim.2019.10.025

Creatinine: From physiology to clinical application

Kianoush Kashani^*, Mitchell H. Rosner, Marlies Ostermann

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

255 Citations (Scopus)

Abstract

Estimating static kidney function accurately and detecting changes in kidney function in a timely fashion are challenging but critically important tasks. Serum creatinine is the most widely used functional biomarker of the kidney. However, its use is associated with substantial shortcomings. Understanding these shortcomings is critical in allowing accurate interpretation of creatinine values and translating them into changes in kidney function. In this review, the pathways involved in creatinine generation and metabolism as well as the techniques involved in measuring creatinine concentrations are discussed. This allows for the discussion of the value and pitfalls in using creatinine as a marker of kidney function. In addition, information regarding alternative functional biomarkers of the kidney is provided.

Original language	English
Journal	European Journal of Internal Medicine
DOIs	https://doi.org/10.1016/j.ejim.2019.10.025
Publication status	Published - 1 Jan 2019

Keywords

Creatine
Creatinine
Cystatin C
GFR
Kidney function
Muscle mass
Sarcopenia

Access to Document

10.1016/j.ejim.2019.10.025

Cite this

@article{a6fc014a7fbd48eeb0779e717aa85d8d,

title = "Creatinine: From physiology to clinical application",

abstract = "Estimating static kidney function accurately and detecting changes in kidney function in a timely fashion are challenging but critically important tasks. Serum creatinine is the most widely used functional biomarker of the kidney. However, its use is associated with substantial shortcomings. Understanding these shortcomings is critical in allowing accurate interpretation of creatinine values and translating them into changes in kidney function. In this review, the pathways involved in creatinine generation and metabolism as well as the techniques involved in measuring creatinine concentrations are discussed. This allows for the discussion of the value and pitfalls in using creatinine as a marker of kidney function. In addition, information regarding alternative functional biomarkers of the kidney is provided.",

keywords = "Creatine, Creatinine, Cystatin C, GFR, Kidney function, Muscle mass, Sarcopenia",

author = "Kianoush Kashani and Rosner, {Mitchell H.} and Marlies Ostermann",

year = "2019",

month = jan,

day = "1",

doi = "10.1016/j.ejim.2019.10.025",

language = "English",

journal = "European Journal of Internal Medicine",

issn = "0953-6205",

publisher = "Elsevier",

}

TY - JOUR

T1 - Creatinine

T2 - From physiology to clinical application

AU - Kashani, Kianoush

AU - Rosner, Mitchell H.

AU - Ostermann, Marlies

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Estimating static kidney function accurately and detecting changes in kidney function in a timely fashion are challenging but critically important tasks. Serum creatinine is the most widely used functional biomarker of the kidney. However, its use is associated with substantial shortcomings. Understanding these shortcomings is critical in allowing accurate interpretation of creatinine values and translating them into changes in kidney function. In this review, the pathways involved in creatinine generation and metabolism as well as the techniques involved in measuring creatinine concentrations are discussed. This allows for the discussion of the value and pitfalls in using creatinine as a marker of kidney function. In addition, information regarding alternative functional biomarkers of the kidney is provided.

AB - Estimating static kidney function accurately and detecting changes in kidney function in a timely fashion are challenging but critically important tasks. Serum creatinine is the most widely used functional biomarker of the kidney. However, its use is associated with substantial shortcomings. Understanding these shortcomings is critical in allowing accurate interpretation of creatinine values and translating them into changes in kidney function. In this review, the pathways involved in creatinine generation and metabolism as well as the techniques involved in measuring creatinine concentrations are discussed. This allows for the discussion of the value and pitfalls in using creatinine as a marker of kidney function. In addition, information regarding alternative functional biomarkers of the kidney is provided.

KW - Creatine

KW - Creatinine

KW - Cystatin C

KW - GFR

KW - Kidney function

KW - Muscle mass

KW - Sarcopenia

UR - http://www.scopus.com/inward/record.url?scp=85075353592&partnerID=8YFLogxK

U2 - 10.1016/j.ejim.2019.10.025

DO - 10.1016/j.ejim.2019.10.025

M3 - Review article

C2 - 31708357

AN - SCOPUS:85075353592

SN - 0953-6205

JO - European Journal of Internal Medicine

JF - European Journal of Internal Medicine

ER -

Creatinine: From physiology to clinical application

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this