Cross-presentation of cell-associated antigens by MHC class I in dendritic cell subsets

Enrique Gutierrez Martinez; Remi Planès; Giorgio Anselmi; Matthew Reynolds; Shinelle Menezes; Aimé Cézaire Adiko; Loredana Saveanu; Pierre Guermonprez

doi:10.3389/fimmu.2015.00363

Cross-presentation of cell-associated antigens by MHC class I in dendritic cell subsets

Enrique Gutierrez Martinez, Remi Planès, Giorgio Anselmi, Matthew Reynolds, Shinelle Menezes, Aimé Cézaire Adiko, Loredana Saveanu, Pierre Guermonprez^*

^*Corresponding author for this work

Research output: Contribution to journal › Literature review › peer-review

130 Citations (Scopus)

Abstract

Dendritic cells (DCs) have the unique ability to pick up dead cells carrying antigens in tissue and migrate to the lymph nodes where they can cross-present cell-associated antigens by MHC class I to CD8⁺ T cells. There is strong in vivo evidence that the mouse XCR1⁺ DCs subset acts as a key player in this process. The intracellular processes underlying cross-presentation remain controversial and several pathways have been proposed. Indeed, a wide number of studies have addressed the cellular process of cross-presentation in vitro using a variety of sources of antigen and antigen-presenting cells. Here, we review the in vivo and in vitro evidence supporting the current mechanistic models and disscuss their physiological relevance to the cross-presentation of cell-associated antigens by DCs subsets.

Original language	English
Article number	363
Journal	Frontiers in Immunology
Volume	6
Issue number	JUL
DOIs	https://doi.org/10.3389/fimmu.2015.00363
Publication status	Published - 17 Jul 2015

Keywords

Antigen processing
Cross-presentation
Cross-priming
Dendritic cells
MHC class I
Phagocytosis

Access to Document

10.3389/fimmu.2015.00363Licence: CC BY

Cite this

@article{29b713dd7fbd4dcb9fd69e36051454a6,

title = "Cross-presentation of cell-associated antigens by MHC class I in dendritic cell subsets",

abstract = "Dendritic cells (DCs) have the unique ability to pick up dead cells carrying antigens in tissue and migrate to the lymph nodes where they can cross-present cell-associated antigens by MHC class I to CD8+ T cells. There is strong in vivo evidence that the mouse XCR1+ DCs subset acts as a key player in this process. The intracellular processes underlying cross-presentation remain controversial and several pathways have been proposed. Indeed, a wide number of studies have addressed the cellular process of cross-presentation in vitro using a variety of sources of antigen and antigen-presenting cells. Here, we review the in vivo and in vitro evidence supporting the current mechanistic models and disscuss their physiological relevance to the cross-presentation of cell-associated antigens by DCs subsets.",

keywords = "Antigen processing, Cross-presentation, Cross-priming, Dendritic cells, MHC class I, Phagocytosis",

author = "{Gutierrez Martinez}, Enrique and Remi Plan{\`e}s and Giorgio Anselmi and Matthew Reynolds and Shinelle Menezes and Adiko, {Aim{\'e} C{\'e}zaire} and Loredana Saveanu and Pierre Guermonprez",

year = "2015",

month = jul,

day = "17",

doi = "10.3389/fimmu.2015.00363",

language = "English",

volume = "6",

journal = "Frontiers in Immunology",

issn = "1664-3224",

publisher = "Frontiers Media",

number = "JUL",

}

TY - JOUR

T1 - Cross-presentation of cell-associated antigens by MHC class I in dendritic cell subsets

AU - Gutierrez Martinez, Enrique

AU - Planès, Remi

AU - Anselmi, Giorgio

AU - Reynolds, Matthew

AU - Menezes, Shinelle

AU - Adiko, Aimé Cézaire

AU - Saveanu, Loredana

AU - Guermonprez, Pierre

PY - 2015/7/17

Y1 - 2015/7/17

N2 - Dendritic cells (DCs) have the unique ability to pick up dead cells carrying antigens in tissue and migrate to the lymph nodes where they can cross-present cell-associated antigens by MHC class I to CD8+ T cells. There is strong in vivo evidence that the mouse XCR1+ DCs subset acts as a key player in this process. The intracellular processes underlying cross-presentation remain controversial and several pathways have been proposed. Indeed, a wide number of studies have addressed the cellular process of cross-presentation in vitro using a variety of sources of antigen and antigen-presenting cells. Here, we review the in vivo and in vitro evidence supporting the current mechanistic models and disscuss their physiological relevance to the cross-presentation of cell-associated antigens by DCs subsets.

AB - Dendritic cells (DCs) have the unique ability to pick up dead cells carrying antigens in tissue and migrate to the lymph nodes where they can cross-present cell-associated antigens by MHC class I to CD8+ T cells. There is strong in vivo evidence that the mouse XCR1+ DCs subset acts as a key player in this process. The intracellular processes underlying cross-presentation remain controversial and several pathways have been proposed. Indeed, a wide number of studies have addressed the cellular process of cross-presentation in vitro using a variety of sources of antigen and antigen-presenting cells. Here, we review the in vivo and in vitro evidence supporting the current mechanistic models and disscuss their physiological relevance to the cross-presentation of cell-associated antigens by DCs subsets.

KW - Antigen processing

KW - Cross-presentation

KW - Cross-priming

KW - Dendritic cells

KW - MHC class I

KW - Phagocytosis

UR - http://www.scopus.com/inward/record.url?scp=84938527735&partnerID=8YFLogxK

U2 - 10.3389/fimmu.2015.00363

DO - 10.3389/fimmu.2015.00363

M3 - Literature review

AN - SCOPUS:84938527735

SN - 1664-3224

VL - 6

JO - Frontiers in Immunology

JF - Frontiers in Immunology

IS - JUL

M1 - 363

ER -

Cross-presentation of cell-associated antigens by MHC class I in dendritic cell subsets

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this