Crossing the endothelial barrier during metastasis

Nicolas Reymond, Ana Barbara Borda D'Agua, Anne J. Ridley*

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

651 Citations (Scopus)

Abstract

During metastasis, cancer cells disseminate to other parts of the body by entering the bloodstream in a process that is called intravasation. They then extravasate at metastatic sites by attaching to endothelial cells that line blood vessels and crossing the vessel walls of tissues or organs. This Review describes how cancer cells cross the endothelial barrier during extravasation and how different receptors, signalling pathways and circulating cells such as leukocytes and platelets contribute to this process. Identification of the mechanisms that underlie cancer cell extravasation could lead to the development of new therapies to reduce metastasis.

Original languageEnglish
Article numberN/A
Pages (from-to)858-870
Number of pages13
JournalNATURE REVIEWS CANCER
Volume13
Issue number12
DOIs
Publication statusPublished - Dec 2013

Keywords

  • BREAST-CANCER CELLS
  • INTEGRIN-MEDIATED ADHESION
  • HEPATOCYTE GROWTH-FACTOR
  • CIRCULATING TUMOR-CELLS
  • B16F1 MELANOMA-CELLS
  • TRANSENDOTHELIAL MIGRATION
  • IN-VIVO
  • UP-REGULATION
  • LUNG METASTASIS
  • ACTIVATED PLATELETS

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