Crosstalk between the nociceptive and immune systems in host defence and disease

TY - JOUR

T1 - Crosstalk between the nociceptive and immune systems in host defence and disease

AU - Mcmahon, Stephen B.

AU - La Russa, Federica

AU - Bennett, David L H

PY - 2015/7/22

Y1 - 2015/7/22

N2 - Nociceptors and immune cells both protect the host from potential threats to homeostasis. There is growing evidence for bidirectional signalling between these two systems, and the underlying mechanisms are beginning to be elucidated. An understanding is emerging of how both the adaptive and innate immune systems can activate and sensitize nociceptors, and, reciprocally, how nociceptors modulate immune cells. In this Review, we discuss how these interactions can be adaptive and useful to the organism but also consider when such signalling might be maladaptive and pathophysiological, contributing to immune-mediated diseases and persistent pain states.

AB - Nociceptors and immune cells both protect the host from potential threats to homeostasis. There is growing evidence for bidirectional signalling between these two systems, and the underlying mechanisms are beginning to be elucidated. An understanding is emerging of how both the adaptive and innate immune systems can activate and sensitize nociceptors, and, reciprocally, how nociceptors modulate immune cells. In this Review, we discuss how these interactions can be adaptive and useful to the organism but also consider when such signalling might be maladaptive and pathophysiological, contributing to immune-mediated diseases and persistent pain states.

UR - http://www.scopus.com/inward/record.url?scp=84932105591&partnerID=8YFLogxK

U2 - 10.1038/nrn3946

DO - 10.1038/nrn3946

M3 - Article

C2 - 26087680

AN - SCOPUS:84932105591

SN - 1471-003X

VL - 16

SP - 389

EP - 402

JO - NATURE REVIEWS NEUROSCIENCE

JF - NATURE REVIEWS NEUROSCIENCE

IS - 7

ER -