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Crosstalk between the nociceptive and immune systems in host defence and disease

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)389-402
Number of pages14
Issue number7
Early online date19 Jun 2015
E-pub ahead of print19 Jun 2015
Published22 Jul 2015

King's Authors


Nociceptors and immune cells both protect the host from potential threats to homeostasis. There is growing evidence for bidirectional signalling between these two systems, and the underlying mechanisms are beginning to be elucidated. An understanding is emerging of how both the adaptive and innate immune systems can activate and sensitize nociceptors, and, reciprocally, how nociceptors modulate immune cells. In this Review, we discuss how these interactions can be adaptive and useful to the organism but also consider when such signalling might be maladaptive and pathophysiological, contributing to immune-mediated diseases and persistent pain states.

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