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Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease

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Genevera I. Allen ; Nicola Amoroso ; Catalina Anghel ; Venkat Balagurusamy ; Christopher J. Bare ; Derek Beaton ; Roberto Bellotti ; David A. Bennett ; Kevin L. Boehme ; Paul C. Boutros ; Laura Caberlotto ; Cristian Caloian ; Frederick Campbell ; Elias Chaibub Neto ; Yu-Chuan Chang ; Beibei Chen ; Chien-Yu Chen ; Ting-Ying Chien ; Tim Clark ; Sudeshna Das ; Christos Davatzikos ; Jieyao Deng ; Donna Dillenberger ; Richard J. B. Dobson ; Qilin Dong ; Jimit Doshi ; Denise Duma ; Rosangela Errico ; Guray Erus ; Evan Everett ; David W. Fardo ; Stephen H. Friend ; Holger Fröhlich ; Jessica Gan ; Peter St George-Hyslop ; Satrajit S. Ghosh ; Enrico Glaab ; Robert C. Green ; Yuanfang Guan ; Ming-Yi Hong ; Chao Huang ; Jinseub Hwang ; Joseph Ibrahim ; Paolo Inglese ; Anandhi Iyappan ; Qijia Jiang ; Yuriko Katsumata ; John S. K. Kauwe ; Arno Klein ; Dehan Kong ; Roland Krause ; Emilie Lalonde ; Mario Lauria ; Eunjee Lee ; Xihui Lin ; Zhandong Liu ; Julie Livingstone ; Benjamin A. Logsdon ; Simon Lovestone ; Tsung-wei Ma ; Ashutosh Malhotra ; Lara M. Mangravite ; Taylor J. Maxwell ; Emily Merrill ; John Nagorski ; Aishwarya Namasivayam ; Manjari Narayan ; Mufassra Naz ; Stephen J. Newhouse ; Thea C. Norman ; Ramil N. Nurtdinov ; Yen-Jen Oyang ; Yudi Pawitan ; Shengwen Peng ; Mette A. Peters ; Stephen R. Piccolo ; Paurush Praveen ; Corrado Priami ; Veronica Y. Sabelnykova ; Philipp Senger ; Xia Shen ; Andy Simmons ; Aristeidis Sotiras ; Gustavo Stolovitzky ; Sabina Tangaro ; Andrea Tateo ; Yi-An Tung ; Nicholas J. Tustison ; Erdem Varol ; George Vradenburg ; Michael W. Weiner ; Guanghua Xiao ; Lei Xie ; Yang Xie ; Jia Xu ; Hojin Yang ; Xiaowei Zhan ; Yunyun Zhou ; Fan Zhu ; Hongtu Zhu ; Shanfeng Zhu

Original languageEnglish
Pages (from-to)645-653
Number of pages9
JournalAlzheimer's & Dementia
Volume12
Issue number6
DOIs
StateE-pub ahead of print - 11 Apr 2016

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Abstract

Identifying accurate biomarkers of cognitive decline is essential for advancing early diagnosis and prevention therapies in Alzheimer's disease. The Alzheimer's disease DREAM Challenge was designed as a computational crowdsourced project to benchmark the current state-of-the-art in predicting cognitive outcomes in Alzheimer's disease based on high dimensional, publicly available genetic and structural imaging data. This meta-analysis failed to identify a meaningful predictor developed from either data modality, suggesting that alternate approaches should be considered for prediction of cognitive performance.

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