Current Status of COVID-19 Therapies and Drug Repositioning Applications

Ozlem Altay, Elyas Mohammadi, Simon Lam, Hasan Turkez, Jan Boren, Jens Nielsen, Mathias Uhlen, Adil Mardinoglu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

71 Citations (Scopus)

Abstract

The rapid and global spread of a new human coronavirus (SARS-CoV-2) has produced an immediate urgency to discover promising targets for the treatment of COVID-19. Drug repositioning is an attractive approach that can facilitate the drug discovery process by repurposing existing pharmaceuticals to treat illnesses other than their primary indications. Here, we review current information concerning the global health issue of COVID-19 including promising approved drugs and ongoing clinical trials for prospective treatment options. In addition, we describe computational approaches to be used in drug repurposing and highlight examples of in silico studies of drug development efforts against SARS-CoV-2.

Original languageEnglish
Article number101303
JournaliScience
Volume23
Issue number7
DOIs
Publication statusPublished - 24 Jul 2020

Keywords

  • Health Sciences
  • Medicine

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