Cutting edge: Histamine inhibits IFN-alpha release from plasmacytoid dendritic cells

A Mazzoni, C A Leifer, G E D Mullen, M N Kennedy, D M Klinman, D M Segal

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)

Abstract

Plasmacytoid dendritic cells (DC) are professional APC and a major source of type I IFN following viral infection. We previously showed that histamine alters the cytokine profiles of maturing monocyte-derived DC resulting in a change from Th1 to Th2 in their T cell polarizing function. In this study, we show that human plasmacytoid DC, activated by either CpG oligodeoxynucleotides or viral infection, also respond to histamine through H2 receptors, leading to a marked down-regulation of IFN-alpha and TNF-alpha and a moderate switch in their capacity to polarize naive T cells. Our findings provide an explanation for low levels of type I IFN frequently observed in atopic individuals
Original languageEnglish
Pages (from-to)2269 - 2273
Number of pages5
JournalJournal of Immunology
Volume170
Issue number5
Publication statusPublished - 2003

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