CYP3A variation, premenopausal estrone levels, and breast cancer risk

Nichola Johnson, Kate Walker, Lorna J Gibson, Nick Orr, Elizabeth Folkerd, Ben Haynes, Claire Palles, Ben Coupland, Minouk Schoemaker, Michael Jones, Peter Broderick, Elinor Sawyer, Michael Kerin, Ian P Tomlinson, Marketa Zvelebil, Sarah Chilcott-Burns, Katarzyna Tomczyk, Gemma Simpson, Jill Williamson, Stephen G HillierGillian Ross, Richard S Houlston, Anthony Swerdlow, Alan Ashworth, Mitch Dowsett, Julian Peto, Isabel Dos Santos Silva, Olivia Fletcher

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28 Citations (Scopus)


Epidemiological studies have provided strong evidence for a role of endogenous sex steroids in the etiology of breast cancer. Our aim was to identify common variants in genes involved in sex steroid synthesis or metabolism that are associated with hormone levels and the risk of breast cancer in premenopausal women.
Original languageEnglish
Pages (from-to)657-69
Number of pages13
JournalJournal of the National Cancer Institute
Issue number9
Publication statusPublished - 2 May 2012


  • Age Factors
  • Odds Ratio
  • Polymorphism, Single Nucleotide
  • Reproductive History
  • Humans
  • Premenopause
  • Menstrual Cycle
  • Glucuronides
  • Linkage Disequilibrium
  • Great Britain
  • Risk Assessment
  • Cytochrome P-450 CYP3A
  • Sex Hormone-Binding Globulin
  • European Continental Ancestry Group
  • Adult
  • Genetic Predisposition to Disease
  • Pregnanediol
  • Mammography
  • Breast Neoplasms
  • Predictive Value of Tests
  • Genotype
  • Life Style
  • Cross-Sectional Studies
  • Risk Factors
  • Case-Control Studies
  • Female
  • Estrone
  • Androgens

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