Cystine calculi: challenging group of stones

Research output: Contribution to journalReview articlepeer-review

48 Citations (Scopus)

Abstract

Cystinuria is an autosomal recessive disorder in renal tubular and intestinal transport of dibasic amino acids, which results in increased urinary excretion of cystine, ornithine, lysine and arginine. It affects 1 in 20 000 people and is caused by a defect in the rBAT gene on chromosome 2. Development of urinary tract cystine calculi is the only clinical manifestation of this disease. Owing to recurrent episodes of stone formation, these patients require a multi-modal approach to management. The role of medical management and minimally invasive surgery was reviewed for the treatment of cystinuria.

Original languageEnglish
Pages (from-to)799-801
Number of pages3
JournalPostgraduate Medical Journal
Volume82
Issue number974
Early online date5 Dec 2006
DOIs
Publication statusPublished - Dec 2006

Keywords

  • Cystine
  • Cystinuria/complications
  • Humans
  • Lithotripsy/methods
  • Nephrostomy, Percutaneous/methods
  • Ureteroscopy/methods
  • Urinary Calculi/chemistry

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