Cytochalasin B inhibits stabilisation of adhesions in fast-aggregating cell systems

T. Partridge; G. E. Jones; R. Gillett

doi:10.1038/253632a0

Cytochalasin B inhibits stabilisation of adhesions in fast-aggregating cell systems

T. Partridge^*, G. E. Jones, R. Gillett

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

THE rapid, naturally occurring aggregation shown by limpet haemocytes ¹ and mammalian blood platelets^2,3 is accompanied by production of prominent microspikes^1,3 and is reversibly inhibited by cytochalasin B (CB)^4,5, thus differing from the slower aggregation of dissociated tissue cells^6-8. Although CB inhibits aggregation of limpet haemocytes in shaken suspension, preformed aggregates shaken in the presence of CB are not disrupted, suggesting that CB inhibits the formation of stable contacts⁵.

Original language	English
Pages (from-to)	632-634
Number of pages	3
Journal	Nature
Volume	253
Issue number	5493
DOIs	https://doi.org/10.1038/253632a0
Publication status	Published - 1 Dec 1975

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title = "Cytochalasin B inhibits stabilisation of adhesions in fast-aggregating cell systems",

abstract = "THE rapid, naturally occurring aggregation shown by limpet haemocytes 1 and mammalian blood platelets2,3 is accompanied by production of prominent microspikes1,3 and is reversibly inhibited by cytochalasin B (CB)4,5, thus differing from the slower aggregation of dissociated tissue cells6-8. Although CB inhibits aggregation of limpet haemocytes in shaken suspension, preformed aggregates shaken in the presence of CB are not disrupted, suggesting that CB inhibits the formation of stable contacts5.",

author = "T. Partridge and Jones, {G. E.} and R. Gillett",

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T1 - Cytochalasin B inhibits stabilisation of adhesions in fast-aggregating cell systems

AU - Partridge, T.

AU - Jones, G. E.

AU - Gillett, R.

PY - 1975/12/1

Y1 - 1975/12/1

N2 - THE rapid, naturally occurring aggregation shown by limpet haemocytes 1 and mammalian blood platelets2,3 is accompanied by production of prominent microspikes1,3 and is reversibly inhibited by cytochalasin B (CB)4,5, thus differing from the slower aggregation of dissociated tissue cells6-8. Although CB inhibits aggregation of limpet haemocytes in shaken suspension, preformed aggregates shaken in the presence of CB are not disrupted, suggesting that CB inhibits the formation of stable contacts5.

AB - THE rapid, naturally occurring aggregation shown by limpet haemocytes 1 and mammalian blood platelets2,3 is accompanied by production of prominent microspikes1,3 and is reversibly inhibited by cytochalasin B (CB)4,5, thus differing from the slower aggregation of dissociated tissue cells6-8. Although CB inhibits aggregation of limpet haemocytes in shaken suspension, preformed aggregates shaken in the presence of CB are not disrupted, suggesting that CB inhibits the formation of stable contacts5.

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JO - Nature

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ER -

Cytochalasin B inhibits stabilisation of adhesions in fast-aggregating cell systems

Abstract

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