Cytochalasin B inhibits stabilisation of adhesions in fast-aggregating cell systems

T. Partridge*, G. E. Jones, R. Gillett

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

THE rapid, naturally occurring aggregation shown by limpet haemocytes 1 and mammalian blood platelets2,3 is accompanied by production of prominent microspikes1,3 and is reversibly inhibited by cytochalasin B (CB)4,5, thus differing from the slower aggregation of dissociated tissue cells6-8. Although CB inhibits aggregation of limpet haemocytes in shaken suspension, preformed aggregates shaken in the presence of CB are not disrupted, suggesting that CB inhibits the formation of stable contacts5.

Original languageEnglish
Pages (from-to)632-634
Number of pages3
JournalNature
Volume253
Issue number5493
DOIs
Publication statusPublished - 1 Dec 1975

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