Cytokines in airway inflammation

Y Riffo-Vasquez, S Pitchford, D Spina

Research output: Contribution to journalLiterature reviewpeer-review

28 Citations (Scopus)


With over 50 potential asthma mediators. cytokines are the latest group of substances which have been investigated for their potential role in this disease. The use of murine models of allergic inflammation has facilitated the investigation of the role of individual cytokines in this response. The use of targeted gene disruption, overexpression of genes and monoclonal antibodies directed against cytokines have allowed a detailed examination of the role cytokines play in IgE production. eosinophil recruitment and bronchial hyperresponsiveness, which are the characteristic features of the asthma phenotype. Despite the introduction of this new methodology, conflicting reports relating to the role of cytokines in allergic inflammation, highlight the complexity of allergic inflammation and challenge the notion that a single cytokine can explain the asthma phenotype. (C) 2000 Elsevier Science Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)833 - 853
Number of pages21
JournalInternational Journal of Biochemistry and Cell Biology
Issue number8
Publication statusPublished - 1 Aug 2000


Dive into the research topics of 'Cytokines in airway inflammation'. Together they form a unique fingerprint.

Cite this