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Cytoreductive nephrectomy in the era of targeted therapies: a review

Research output: Contribution to journalArticle

Nisha Pindoria, Nicholas Raison, Gideon Blecher, Rick Catterwell, Prokar Dasgupta

Original languageEnglish
Pages (from-to)320–328
Number of pages9
JournalBJU International
Issue number3
Publication statusE-pub ahead of print - 2 May 2017


  • Cytoreductive nephrectomy in the era_PINDORIA_Publishedonline2May2017_GREEN AAM

    Cytoreductive_therapy_in_the_era_PINDORIA_Publishedonline2May2017_GREEN_AAM.pdf, 211 KB, application/pdf


    Accepted author manuscript


    This is the peer reviewed version of the following article, published in BJU International, v. 120 issue 3, September 2017, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

King's Authors


In the pre-targeted therapy era, palliative cytoreductive nephrectomy combined with cytokine immunotherapy was the standard treatment protocol for the management of metastatic renal cell carcinoma. The introduction of targeted therapies has improved response rates, median survival and overall prognosis when compared to immunotherapy. The role of cytoreductive nephrectomy in providing an independent survival advantage when used alongside immunotherapy has been demonstrated by two randomised controlled trials. However, with the new shift in improved treatment outcomes from cytokine immunotherapy to targeted therapies, the continuing role of cytoreductive nephrectomy as a viable surgical treatment method remains controversial.

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