Deciphering the mechanisms of developmental disorders: Phenotype analysis of embryos from mutant mouse lines

Robert Wilson*, Christina McGuire, Timothy Mohun, David Adams, Richard Baldock, Shoumo Bhattacharya, John Collins, Elena Fineberg, Lydia Firminger, Antonella Galli, Stefan Geyer, Mark Grifiths, Amira Hassan, Myriam Hemberger, Corinne Houart, David Melvin, Fabrice Prin, Ramiro Ramirez-Solis, Lukas Reissig, Elizabeth RobertsonJulia Rose, Jurgen Schneider, Jim Smith, Dorota Szumska, Catherine Tudor, Aude Vernet, Wolfgang Weninger, Jacqui White

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)
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Abstract

The Deciphering the Mechanisms of Developmental Disorders (DMDD) consortium is a research programme set up to identify genes in the mouse, which if mutated (or knocked-out) result in embryonic lethality when homozygous, and initiate the study of why disruption of their function has such profound effects on embryo development and survival. The project uses a combination of comprehensive high resolution 3D imaging and tissue histology to identify abnormalities in embryo and placental structures of embryonic lethal lines. The image data we have collected and the phenotypes scored are freely available through the project website (http://dmdd.org.uk). In this article we describe the web interface to the images that allows the embryo data to be viewed at full resolution in different planes, discuss how to search the database for a phenotype, and our approach to organising the data for an embryo and a mutant line so it is easy to comprehend and intuitive to navigate.

Original languageEnglish
Pages (from-to)D855-D861
JournalNucleic Acids Research
Volume44
Issue numberD1
DOIs
Publication statusPublished - 11 Aug 2016

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