Decision making and set shifting impairments are associated with distinct symptom dimensions in obsessive-compulsive disorder

TY - JOUR

T1 - Decision making and set shifting impairments are associated with distinct symptom dimensions in obsessive-compulsive disorder

AU - Lawrence, Natalia S

AU - Wooderson, Sarah

AU - Mataix-Cols, David

AU - David, Rhodri

AU - Speckens, Anne

AU - Phillips, Mary L

N1 - ((c) 2006 APA, all rights reserved).

PY - 2006/7

Y1 - 2006/7

N2 - Obsessive-compulsive disorder (OCD) is clinically heterogeneous. The authors examined how specific OCD symptom dimensions were related to neuropsychological functions using multiple regression analyses. A total of 39 OCD patients and 40 controls completed the Iowa Gambling Task (IGT; A. Bechara, A. R. Damasio, H. Damasio, & S. W. Anderson, 1994), which is a test of decision making, and the Wisconsin Card Sorting Test (R. K. Heaton, 1981), which is a test of set shifting. OCD patients and controls showed comparable decision making. However, patients with prominent hoarding symptoms showed impaired decision making on the IGT as well as reduced skin conductance responses. OCD patients had poorer set shifting abilities than controls, and symmetry/ordering symptoms were negatively associated with set shifting. These results help explain previous inconsistent findings in neuropsychological research in OCD and support recent neuroimaging data showing dissociable neural mechanisms involved in mediating the different OCD symptom dimensions

AB - Obsessive-compulsive disorder (OCD) is clinically heterogeneous. The authors examined how specific OCD symptom dimensions were related to neuropsychological functions using multiple regression analyses. A total of 39 OCD patients and 40 controls completed the Iowa Gambling Task (IGT; A. Bechara, A. R. Damasio, H. Damasio, & S. W. Anderson, 1994), which is a test of decision making, and the Wisconsin Card Sorting Test (R. K. Heaton, 1981), which is a test of set shifting. OCD patients and controls showed comparable decision making. However, patients with prominent hoarding symptoms showed impaired decision making on the IGT as well as reduced skin conductance responses. OCD patients had poorer set shifting abilities than controls, and symmetry/ordering symptoms were negatively associated with set shifting. These results help explain previous inconsistent findings in neuropsychological research in OCD and support recent neuroimaging data showing dissociable neural mechanisms involved in mediating the different OCD symptom dimensions

U2 - 10.1037/0894-4105.20.4.409

DO - 10.1037/0894-4105.20.4.409

M3 - Article

C2 - 16846259

VL - 20

SP - 409

EP - 419

JO - Neuropsychology

JF - Neuropsychology

IS - 4

ER -