TY - UNPB
T1 - Decoding functional hematopoietic progenitor cells in the adult human lung
AU - Conrad, Catharina
AU - Magnen, Melia
AU - Tsui, Jessica
AU - Wismer, Harrison
AU - Naser, Mohammad
AU - Venkataramani, Urmila
AU - Samad, Bushra
AU - Cleary, Simon J
AU - Qiu, Longhui
AU - Tian, Jennifer J
AU - De Giovanni, Marco
AU - Mende, Nicole
AU - Passegue, Emmanuelle
AU - Laurenti, Elisa
AU - Combes, Alexis J
AU - Looney, Mark R
PY - 2024/2/16
Y1 - 2024/2/16
N2 - The bone marrow is the main site of blood cell production in adults, however, rare pools of hematopoietic stem and progenitor cells with self-renewal and differentiation potential have been found in extramedullary organs. The lung is primarily known for its role in gas exchange but has recently been described as a site of blood production in mice. Here, we show that functional hematopoietic precursors reside in the extravascular spaces of the human lung, at a frequency similar to the bone marrow, and are capable of proliferation and engraftment. The organ-specific gene signature of pulmonary and medullary CD34+ hematopoietic progenitors indicates greater baseline activation of immune, megakaryocyte/platelet and erythroid-related pathways in lung progenitors. Spatial transcriptomics mapped blood progenitors in the lung to a vascular-rich alveolar interstitium niche. These results identify the lung as a pool for uniquely programmed blood stem and progenitor cells with the potential to support hematopoiesis in humans.
AB - The bone marrow is the main site of blood cell production in adults, however, rare pools of hematopoietic stem and progenitor cells with self-renewal and differentiation potential have been found in extramedullary organs. The lung is primarily known for its role in gas exchange but has recently been described as a site of blood production in mice. Here, we show that functional hematopoietic precursors reside in the extravascular spaces of the human lung, at a frequency similar to the bone marrow, and are capable of proliferation and engraftment. The organ-specific gene signature of pulmonary and medullary CD34+ hematopoietic progenitors indicates greater baseline activation of immune, megakaryocyte/platelet and erythroid-related pathways in lung progenitors. Spatial transcriptomics mapped blood progenitors in the lung to a vascular-rich alveolar interstitium niche. These results identify the lung as a pool for uniquely programmed blood stem and progenitor cells with the potential to support hematopoiesis in humans.
U2 - 10.21203/rs.3.rs-3576483/v1
DO - 10.21203/rs.3.rs-3576483/v1
M3 - Preprint
C2 - 38077002
T3 - Research square
BT - Decoding functional hematopoietic progenitor cells in the adult human lung
ER -