Decreased centrality of subcortical regions during the transition to adolescence: A functional connectivity study

João Ricardo Sato; Giovanni Abrahão Salum; Ary Gadelha; Gilson Vieira; André Zugman; Felipe Almeida Picon; Pedro Mario Pan; Marcelo Queiroz Hoexter; Mauricio Anés; Luciana Monteiro Moura; Marco Antonio Gomes Del'Aquilla; Nicolas Crossley; Edson Amaro; Philip Mcguire; Acioly L T Lacerda; Luis Augusto Rohde; Euripedes Constantino Miguel; Andrea Parolin Jackowski; Rodrigo Affonseca Bressan

doi:10.1016/j.neuroimage.2014.09.063

Decreased centrality of subcortical regions during the transition to adolescence: A functional connectivity study

João Ricardo Sato^*, Giovanni Abrahão Salum, Ary Gadelha, Gilson Vieira, André Zugman, Felipe Almeida Picon, Pedro Mario Pan, Marcelo Queiroz Hoexter, Mauricio Anés, Luciana Monteiro Moura, Marco Antonio Gomes Del'Aquilla, Nicolas Crossley, Edson Amaro, Philip Mcguire, Acioly L T Lacerda, Luis Augusto Rohde, Euripedes Constantino Miguel, Andrea Parolin Jackowski, Rodrigo Affonseca Bressan

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Investigations of brain maturation processes are a key step to understand the cognitive and emotional changes of adolescence. Although structural imaging findings have delineated clear brain developmental trajectories for typically developing individuals, less is known about the functional changes of this sensitive development period. Developmental changes, such as abstract thought, complex reasoning, and emotional and inhibitory control, have been associated with more prominent cortical control. The aim of this study is to assess brain networks connectivity changes in a large sample of 7- to 15-year-old subjects, testing the hypothesis that cortical regions will present an increasing relevance in commanding the global network. Functional magnetic resonance imaging (fMRI) data were collected in a sample of 447 typically developing children from a Brazilian community sample who were submitted to a resting state acquisition protocol. The fMRI data were used to build a functional weighted graph from which eigenvector centrality (EVC) was extracted. For each brain region (a node of the graph), the age-dependent effect on EVC was statistically tested and the developmental trajectories were estimated using polynomial functions.Our findings show that angular gyrus become more central during this maturation period, while the caudate; cerebellar tonsils, pyramis, thalamus; fusiform, parahippocampal and inferior semilunar lobe become less central. In conclusion, we report a novel finding of an increasing centrality of the angular gyrus during the transition to adolescence, with a decreasing centrality of many subcortical and cerebellar regions.

Original language	English
Pages (from-to)	44-51
Number of pages	8
Journal	NeuroImage
Volume	104
DOIs	https://doi.org/10.1016/j.neuroimage.2014.09.063
Publication status	Published - 1 Jan 2015

Keywords

Children
Graph
Networks
Neurodevelopment
Neuroimaging

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10.1016/j.neuroimage.2014.09.063

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Sato, J. R., Salum, G. A., Gadelha, A., Vieira, G., Zugman, A., Picon, F. A., Pan, P. M., Hoexter, M. Q., Anés, M., Moura, L. M., Del'Aquilla, M. A. G., Crossley, N., Amaro, E., Mcguire, P., Lacerda, A. L. T., Rohde, L. A., Miguel, E. C., Jackowski, A. P., & Bressan, R. A. (2015). Decreased centrality of subcortical regions during the transition to adolescence: A functional connectivity study. NeuroImage, 104, 44-51. https://doi.org/10.1016/j.neuroimage.2014.09.063

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title = "Decreased centrality of subcortical regions during the transition to adolescence: A functional connectivity study",

abstract = "Investigations of brain maturation processes are a key step to understand the cognitive and emotional changes of adolescence. Although structural imaging findings have delineated clear brain developmental trajectories for typically developing individuals, less is known about the functional changes of this sensitive development period. Developmental changes, such as abstract thought, complex reasoning, and emotional and inhibitory control, have been associated with more prominent cortical control. The aim of this study is to assess brain networks connectivity changes in a large sample of 7- to 15-year-old subjects, testing the hypothesis that cortical regions will present an increasing relevance in commanding the global network. Functional magnetic resonance imaging (fMRI) data were collected in a sample of 447 typically developing children from a Brazilian community sample who were submitted to a resting state acquisition protocol. The fMRI data were used to build a functional weighted graph from which eigenvector centrality (EVC) was extracted. For each brain region (a node of the graph), the age-dependent effect on EVC was statistically tested and the developmental trajectories were estimated using polynomial functions.Our findings show that angular gyrus become more central during this maturation period, while the caudate; cerebellar tonsils, pyramis, thalamus; fusiform, parahippocampal and inferior semilunar lobe become less central. In conclusion, we report a novel finding of an increasing centrality of the angular gyrus during the transition to adolescence, with a decreasing centrality of many subcortical and cerebellar regions.",

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Sato, JR, Salum, GA, Gadelha, A, Vieira, G, Zugman, A, Picon, FA, Pan, PM, Hoexter, MQ, Anés, M, Moura, LM, Del'Aquilla, MAG, Crossley, N, Amaro, E, Mcguire, P, Lacerda, ALT, Rohde, LA, Miguel, EC, Jackowski, AP & Bressan, RA 2015, 'Decreased centrality of subcortical regions during the transition to adolescence: A functional connectivity study', NeuroImage, vol. 104, pp. 44-51. https://doi.org/10.1016/j.neuroimage.2014.09.063

TY - JOUR

T1 - Decreased centrality of subcortical regions during the transition to adolescence

T2 - A functional connectivity study

AU - Sato, João Ricardo

AU - Salum, Giovanni Abrahão

AU - Gadelha, Ary

AU - Vieira, Gilson

AU - Zugman, André

AU - Picon, Felipe Almeida

AU - Pan, Pedro Mario

AU - Hoexter, Marcelo Queiroz

AU - Anés, Mauricio

AU - Moura, Luciana Monteiro

AU - Del'Aquilla, Marco Antonio Gomes

AU - Crossley, Nicolas

AU - Amaro, Edson

AU - Mcguire, Philip

AU - Lacerda, Acioly L T

AU - Rohde, Luis Augusto

AU - Miguel, Euripedes Constantino

AU - Jackowski, Andrea Parolin

AU - Bressan, Rodrigo Affonseca

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Investigations of brain maturation processes are a key step to understand the cognitive and emotional changes of adolescence. Although structural imaging findings have delineated clear brain developmental trajectories for typically developing individuals, less is known about the functional changes of this sensitive development period. Developmental changes, such as abstract thought, complex reasoning, and emotional and inhibitory control, have been associated with more prominent cortical control. The aim of this study is to assess brain networks connectivity changes in a large sample of 7- to 15-year-old subjects, testing the hypothesis that cortical regions will present an increasing relevance in commanding the global network. Functional magnetic resonance imaging (fMRI) data were collected in a sample of 447 typically developing children from a Brazilian community sample who were submitted to a resting state acquisition protocol. The fMRI data were used to build a functional weighted graph from which eigenvector centrality (EVC) was extracted. For each brain region (a node of the graph), the age-dependent effect on EVC was statistically tested and the developmental trajectories were estimated using polynomial functions.Our findings show that angular gyrus become more central during this maturation period, while the caudate; cerebellar tonsils, pyramis, thalamus; fusiform, parahippocampal and inferior semilunar lobe become less central. In conclusion, we report a novel finding of an increasing centrality of the angular gyrus during the transition to adolescence, with a decreasing centrality of many subcortical and cerebellar regions.

AB - Investigations of brain maturation processes are a key step to understand the cognitive and emotional changes of adolescence. Although structural imaging findings have delineated clear brain developmental trajectories for typically developing individuals, less is known about the functional changes of this sensitive development period. Developmental changes, such as abstract thought, complex reasoning, and emotional and inhibitory control, have been associated with more prominent cortical control. The aim of this study is to assess brain networks connectivity changes in a large sample of 7- to 15-year-old subjects, testing the hypothesis that cortical regions will present an increasing relevance in commanding the global network. Functional magnetic resonance imaging (fMRI) data were collected in a sample of 447 typically developing children from a Brazilian community sample who were submitted to a resting state acquisition protocol. The fMRI data were used to build a functional weighted graph from which eigenvector centrality (EVC) was extracted. For each brain region (a node of the graph), the age-dependent effect on EVC was statistically tested and the developmental trajectories were estimated using polynomial functions.Our findings show that angular gyrus become more central during this maturation period, while the caudate; cerebellar tonsils, pyramis, thalamus; fusiform, parahippocampal and inferior semilunar lobe become less central. In conclusion, we report a novel finding of an increasing centrality of the angular gyrus during the transition to adolescence, with a decreasing centrality of many subcortical and cerebellar regions.

KW - Children

KW - Graph

KW - Networks

KW - Neurodevelopment

KW - Neuroimaging

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U2 - 10.1016/j.neuroimage.2014.09.063

DO - 10.1016/j.neuroimage.2014.09.063

M3 - Article

SN - 1053-8119

VL - 104

SP - 44

EP - 51

JO - NeuroImage

JF - NeuroImage

ER -

Decreased centrality of subcortical regions during the transition to adolescence: A functional connectivity study

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Keywords

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