Deep sleep divides the cortex into opposite modes of anatomical–functional coupling

Enzo Tagliazucchi; Nicolas Crossley Karmelic; Edward T. Bullmore; Helmut Laufs

doi:10.1007/s00429-015-1162-0

Deep sleep divides the cortex into opposite modes of anatomical–functional coupling

Enzo Tagliazucchi^*, Nicolas Crossley Karmelic, Edward T. Bullmore, Helmut Laufs

^*Corresponding author for this work

Psychosis Studies

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

The coupling of anatomical and functional connectivity at rest suggests that anatomy is essential for wake-typical activity patterns. Here, we study the development of this coupling from wakefulness to deep sleep. Globally, similarity between whole-brain anatomical and functional connectivity networks increased during deep sleep. Regionally, we found differential coupling: during sleep, functional connectivity of primary cortices resembled more the underlying anatomical connectivity, while we observed the opposite in associative cortices. Increased anatomical–functional similarity in sensory areas is consistent with their stereotypical, cross-modal response to the environment during sleep. In distinction, looser coupling—relative to wakeful rest—in higher order integrative cortices suggests that sleep actively disrupts default patterns of functional connectivity in regions essential for the conscious access of information and that anatomical connectivity acts as an anchor for the restoration of their functionality upon awakening.

Original language	English
Pages (from-to)	1-14
Number of pages	14
Journal	Brain structure & function
DOIs	https://doi.org/10.1007/s00429-015-1162-0
Publication status	Accepted/In press - 9 Dec 2015

Keywords

Anatomical connectivity
Consciousness
Functional connectivity
Sleep

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10.1007/s00429-015-1162-0

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AU - Tagliazucchi, Enzo

AU - Crossley Karmelic, Nicolas

AU - Bullmore, Edward T.

AU - Laufs, Helmut

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Deep sleep divides the cortex into opposite modes of anatomical–functional coupling

Abstract

Keywords

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