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Definitions of acute renal dysfunction: an evolving clinical and biomarker paradigm

Research output: Contribution to journalArticlepeer-review

Marlies Ostermann, Vin Cent Wu, Dmitry Sokolov, Nuttha Lumlertgul

Original languageEnglish
Pages (from-to)553-559
Number of pages7
JournalCurrent opinion in critical care
Issue number6
Published1 Dec 2021

Bibliographical note

Publisher Copyright: Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

King's Authors


PURPOSE OF REVIEW: The current definition and classification of acute kidney injury (AKI) has limitations and shortcomings, which impact clinical management. The aim of this review is to highlight recent advances in our understanding of the pathophysiology and epidemiology of AKI, which impacts management and offers opportunities. RECENT FINDINGS: Kidney damage varies according to the type of primary insult, secondary effects and mitigating responses and leads to distinct molecular, cellular and functional changes. Different sub-types of AKI with varying clinical phenotypes, recovery patterns and responses to therapeutic interventions have been identified. New tools to identify and characterize these AKI sub-types are available with the potential opportunity for individualized timely aetiology-based management of AKI. SUMMARY: The identification of different sub-phenotypes of AKI based on genetic, molecular, cellular and functional pathophysiological changes following potential nephrotoxic exposures is possible with new technologies. This offers opportunities for personalized management of AKI and supports the call for a refinement of the existing AKI criteria.

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