Dehydration and venous thromboembolism after acute stroke

J Kelly; B J Hunt; R R Lewis; R Swaminathan; A Moody; P T Seed; A Rudd

doi:10.1093/qjmed/hch050

Dehydration and venous thromboembolism after acute stroke

J Kelly, B J Hunt, R R Lewis, R Swaminathan, A Moody, P T Seed, A Rudd

Research output: Contribution to journal › Article › peer-review

123 Citations (Scopus)

Abstract

Background: Although it is widely assumed that dehydration predisposes to venous thromboembolism (VTE), there are no clinical studies to support this. Aim: To evaluate the relationship between biochemical indices of dehydration and VTE after acute ischaemic stroke (AIS). Design: Prospective observational study. Methods: Unselected AIS patients (n=102) receiving standard thromboprophylaxis with aspirin and graded compression stockings, underwent serial measurements of serum urea, creatinine and osmolality, and were screened for VTE using magnetic resonance direct thrombus imaging. Results: Serum osmolality of >297 mOsm/kg, urea >7.5 mmol/l and urea:creatinine ratio (mmol:mmol) >80 a few days post-AIS were associated with odds ratios for VTE of, respectively, 4.7, 2.8 and 3.4 (p = 0.02, 0.05, 0.02) on multivariable analysis. Discussion: Dehydration after AIS is strongly independently associated with VTE, reinforcing the importance of maintaining adequate hydration in these patients.

Original language	English
Pages (from-to)	293 - 296
Number of pages	4
Journal	QJM
Volume	97
Issue number	5
DOIs	https://doi.org/10.1093/qjmed/hch050
Publication status	Published - May 2004

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/qjmed/hch050

Cite this

@article{081d2065d6c04bfcabefc7e4ace5244a,

title = "Dehydration and venous thromboembolism after acute stroke",

abstract = "Background: Although it is widely assumed that dehydration predisposes to venous thromboembolism (VTE), there are no clinical studies to support this. Aim: To evaluate the relationship between biochemical indices of dehydration and VTE after acute ischaemic stroke (AIS). Design: Prospective observational study. Methods: Unselected AIS patients (n=102) receiving standard thromboprophylaxis with aspirin and graded compression stockings, underwent serial measurements of serum urea, creatinine and osmolality, and were screened for VTE using magnetic resonance direct thrombus imaging. Results: Serum osmolality of >297 mOsm/kg, urea >7.5 mmol/l and urea:creatinine ratio (mmol:mmol) >80 a few days post-AIS were associated with odds ratios for VTE of, respectively, 4.7, 2.8 and 3.4 (p = 0.02, 0.05, 0.02) on multivariable analysis. Discussion: Dehydration after AIS is strongly independently associated with VTE, reinforcing the importance of maintaining adequate hydration in these patients.",

author = "J Kelly and Hunt, {B J} and Lewis, {R R} and R Swaminathan and A Moody and Seed, {P T} and A Rudd",

year = "2004",

month = may,

doi = "10.1093/qjmed/hch050",

language = "English",

volume = "97",

pages = "293 -- 296",

journal = "QJM",

publisher = "OXFORD UNIV PRESS",

number = "5",

}

TY - JOUR

T1 - Dehydration and venous thromboembolism after acute stroke

AU - Kelly, J

AU - Hunt, B J

AU - Lewis, R R

AU - Swaminathan, R

AU - Moody, A

AU - Seed, P T

AU - Rudd, A

PY - 2004/5

Y1 - 2004/5

N2 - Background: Although it is widely assumed that dehydration predisposes to venous thromboembolism (VTE), there are no clinical studies to support this. Aim: To evaluate the relationship between biochemical indices of dehydration and VTE after acute ischaemic stroke (AIS). Design: Prospective observational study. Methods: Unselected AIS patients (n=102) receiving standard thromboprophylaxis with aspirin and graded compression stockings, underwent serial measurements of serum urea, creatinine and osmolality, and were screened for VTE using magnetic resonance direct thrombus imaging. Results: Serum osmolality of >297 mOsm/kg, urea >7.5 mmol/l and urea:creatinine ratio (mmol:mmol) >80 a few days post-AIS were associated with odds ratios for VTE of, respectively, 4.7, 2.8 and 3.4 (p = 0.02, 0.05, 0.02) on multivariable analysis. Discussion: Dehydration after AIS is strongly independently associated with VTE, reinforcing the importance of maintaining adequate hydration in these patients.

AB - Background: Although it is widely assumed that dehydration predisposes to venous thromboembolism (VTE), there are no clinical studies to support this. Aim: To evaluate the relationship between biochemical indices of dehydration and VTE after acute ischaemic stroke (AIS). Design: Prospective observational study. Methods: Unselected AIS patients (n=102) receiving standard thromboprophylaxis with aspirin and graded compression stockings, underwent serial measurements of serum urea, creatinine and osmolality, and were screened for VTE using magnetic resonance direct thrombus imaging. Results: Serum osmolality of >297 mOsm/kg, urea >7.5 mmol/l and urea:creatinine ratio (mmol:mmol) >80 a few days post-AIS were associated with odds ratios for VTE of, respectively, 4.7, 2.8 and 3.4 (p = 0.02, 0.05, 0.02) on multivariable analysis. Discussion: Dehydration after AIS is strongly independently associated with VTE, reinforcing the importance of maintaining adequate hydration in these patients.

UR - http://www.scopus.com/inward/record.url?scp=2442662737&partnerID=8YFLogxK

U2 - 10.1093/qjmed/hch050

DO - 10.1093/qjmed/hch050

M3 - Article

VL - 97

SP - 293

EP - 296

JO - QJM

JF - QJM

IS - 5

ER -

Dehydration and venous thromboembolism after acute stroke

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this