Dehydration and venous thromboembolism after acute stroke

J Kelly, B J Hunt, R R Lewis, R Swaminathan, A Moody, P T Seed, A Rudd

Research output: Contribution to journalArticlepeer-review

115 Citations (Scopus)

Abstract

Background: Although it is widely assumed that dehydration predisposes to venous thromboembolism (VTE), there are no clinical studies to support this. Aim: To evaluate the relationship between biochemical indices of dehydration and VTE after acute ischaemic stroke (AIS). Design: Prospective observational study. Methods: Unselected AIS patients (n=102) receiving standard thromboprophylaxis with aspirin and graded compression stockings, underwent serial measurements of serum urea, creatinine and osmolality, and were screened for VTE using magnetic resonance direct thrombus imaging. Results: Serum osmolality of >297 mOsm/kg, urea >7.5 mmol/l and urea:creatinine ratio (mmol:mmol) >80 a few days post-AIS were associated with odds ratios for VTE of, respectively, 4.7, 2.8 and 3.4 (p = 0.02, 0.05, 0.02) on multivariable analysis. Discussion: Dehydration after AIS is strongly independently associated with VTE, reinforcing the importance of maintaining adequate hydration in these patients.
Original languageEnglish
Pages (from-to)293 - 296
Number of pages4
JournalQJM
Volume97
Issue number5
DOIs
Publication statusPublished - May 2004

Fingerprint

Dive into the research topics of 'Dehydration and venous thromboembolism after acute stroke'. Together they form a unique fingerprint.

Cite this