Dendritic Cells as a Tool to Induce Transplantation Tolerance: Obstacles and Opportunities

TY - JOUR

T1 - Dendritic Cells as a Tool to Induce Transplantation Tolerance: Obstacles and Opportunities

AU - van Kooten, Cees

AU - Lombardi, Giovanna

AU - Gelderman, Kyra A.

AU - Sagoo, Pervinder

AU - Buckland, Matthew

AU - Lechler, Robert

AU - Cuturi, Maria Cristina

PY - 2011/1/15

Y1 - 2011/1/15

N2 - Dendritic cells are the key component to regulate and coordinate adaptive immune responses, including tolerance. This overview will briefly summarize different strategies to generate tolerogenic dendritic cell and the in vivo use of these cells in experimental transplantation models. We discuss some obstacles and possible solutions including alternative strategies for the use of negative vaccination in the context of organ transplantation.

AB - Dendritic cells are the key component to regulate and coordinate adaptive immune responses, including tolerance. This overview will briefly summarize different strategies to generate tolerogenic dendritic cell and the in vivo use of these cells in experimental transplantation models. We discuss some obstacles and possible solutions including alternative strategies for the use of negative vaccination in the context of organ transplantation.

U2 - 10.1097/TP.0b013e31820263b3

DO - 10.1097/TP.0b013e31820263b3

M3 - Article

VL - 91

SP - 2

EP - 7

JO - Transplantation

JF - Transplantation

IS - 1

ER -