Dendritic Cells as a Tool to Induce Transplantation Tolerance: Obstacles and Opportunities

Cees van Kooten, Giovanna Lombardi, Kyra A. Gelderman, Pervinder Sagoo, Matthew Buckland, Robert Lechler, Maria Cristina Cuturi

Research output: Contribution to journalArticlepeer-review

65 Citations (Scopus)

Abstract

Dendritic cells are the key component to regulate and coordinate adaptive immune responses, including tolerance. This overview will briefly summarize different strategies to generate tolerogenic dendritic cell and the in vivo use of these cells in experimental transplantation models. We discuss some obstacles and possible solutions including alternative strategies for the use of negative vaccination in the context of organ transplantation.
Original languageEnglish
Pages (from-to)2 - 7
Number of pages6
JournalTransplantation
Volume91
Issue number1
DOIs
Publication statusPublished - 15 Jan 2011

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