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Dendritic cells, T cells and their interaction in rheumatoid arthritis

Research output: Contribution to journalArticlepeer-review

P. Wehr, H. Purvis, S. C. Law, R. Thomas

Original languageEnglish
Pages (from-to)12-27
Number of pages16
JournalClinical and Experimental Immunology
Volume196
Issue number1
Early online date27 Dec 2018
DOIs
Accepted/In press10 Dec 2018
E-pub ahead of print27 Dec 2018
Published18 Mar 2019

King's Authors

Abstract

Dendritic cells (DCs) are the key professional antigen-presenting cells which bridge innate and adaptive immune responses, inducing the priming and differentiation of naive to effector CD4+ T cells, the cross-priming of CD8+ T cells and the promotion of B cell antibody responses. DCs also play a critical role in the maintenance of immune homeostasis and tolerance. DC–T cell interactions underpin the generation of an autoimmune response in rheumatoid arthritis (RA). Here we describe the function of DCs and review evidence for DC and T cell involvement in RA pathogenesis, in particular through the presentation of self-peptide by DCs that triggers differentiation and activation of autoreactive T cells. Finally, we discuss the emerging field of targeting the DC–T cell interaction for antigen-specific immunotherapy of RA.

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