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Densité des vaisseaux péripapillaires et de la tête du nerf optique des sujets avec glaucome et sains d'origine afro-caribéenne et européenne: une étude pilote

Research output: Contribution to journalArticlepeer-review

L. Salazar-Quiñones, C. Yu-Wai-Man, A. De Antonio Ramirez, C. D. Méndez-Hernández, A. Daas, J. Garcia Feijoo, E. Guzman-Almagro, C. Fernández-Pérez, K. Sheng Lim

Translated title of the contributionPeripapillary and optic nerve head vessel density of glaucoma and healthy subjects from Afro-Caribbean and European descent: A pilot study
Original languageFrench
Pages (from-to)207-215
Number of pages9
JournalJournal Francais d'Ophtalmologie
Volume45
Issue number2
Early online date29 Jan 2022
DOIs
Accepted/In press20 Jul 2021
E-pub ahead of print29 Jan 2022
PublishedFeb 2022

Bibliographical note

Funding Information: Unrestricted grant supported by Spanish Glaucoma Society through the Young Research Award 2018. This organisation had no role in the design or conduct of this research. Publisher Copyright: © 2021

King's Authors

Abstract

Purpose: To compare the peripapillary and optic nerve head vessel density (PP-ONH VD) between glaucoma patients (all, early, moderated, and advanced) and healthy subjects of Afro-Caribbean descent (AD) and European descent (ED). Methods: This was a cross-sectional study. One eye was evaluated in 90 subjects, including 66 glaucoma patients and 24 healthy subjects, who underwent PP-ONH VD imaging using SPECTRALIS® Optical Coherence Tomography Angiography (OCT-A). We analysed the superficial vascular complex using the AngioTool version 0.6a software. The correlation between the PP-ONH VD and visual field mean deviation (MD) was evaluated using a scatter plot and Spearman's rho correlation coefficient. Results: Among the healthy subjects, the AD group had a lower superficial PP-ONH VD [43.29 ± 3.25% (mean ± standard deviation)] than the ED group (46.06 ± 1.75%) (P = 0.016). Overall, superficial PP-ONH VD did not show any significant differences between the total AD and ED glaucoma patients or in the subgroup analyses (early/moderate/advanced) (AD: 32.73 ± 6.70%, 37.11 ± 5.72%, 32.48 ± 5.73%, 27.76 ± 4.74%, respectively; ED: 33.94 ± 6.89%, 38.52 ± 3.82%, 35.56 ± 4.18%; 27.65 ± 6.31%, respectively) (P > 0.05 for all). A strong, statistically significant correlation was established between vessel density and mean deviation among AD and ED glaucoma patients (r = 0.709 and r = 0.704, respectively) (P < 0.001 for both). Conclusion: This pilot study shows that healthy subjects of AD had lower peripapillary and optic nerve head superficial vessel density than healthy subjects of ED, but no significant differences were found between AD and ED glaucoma groups (all, early, moderate, or advanced).

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