Dental anomalies in first-degree relatives of transposed canine probands

TY - JOUR

T1 - Dental anomalies in first-degree relatives of transposed canine probands

AU - Bartolo, Adriana

AU - Calleja, Neville

AU - McDonald, Fraser

AU - Camilleri, Simon

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The aim of this study was to investigate and compare the inheritance pattern and prevalence of inheritable dental anomalies in a sample of patients with maxillary canine - first premolar transposition and their first-degree relatives with a sample of palatally displaced canine families. Thirty-five consecutive maxillary canine - first premolar transposition probands and 111 first-degree relatives were matched to 35 consecutive palatally displaced canine probands and 115 first-degree relatives. These were assessed for palatally displaced canines and incisor-premolar hypodontia. Parental age at birth of the proband was also noted. The results revealed that (i) there is no difference in the overall prevalence of palatally displaced canine or incisor-premolar hypodontia between the groups of relatives; (ii) first-degree relatives of bilateral palatally displaced canine probands have a higher prevalence of palatally displaced canine and incisor-premolar hypodontia than those with unilateral palatally displaced canine; and (iii) maternal age at birth of the maxillary canine - first premolar transposition probands was significantly higher than that of the palatally displaced canine probands. The results suggest that maxillary canine - first premolar transposition and palatally displaced canine are unlikely to be different genetic entities and also indicate environmental or epigenetic influences on dental development.

AB - The aim of this study was to investigate and compare the inheritance pattern and prevalence of inheritable dental anomalies in a sample of patients with maxillary canine - first premolar transposition and their first-degree relatives with a sample of palatally displaced canine families. Thirty-five consecutive maxillary canine - first premolar transposition probands and 111 first-degree relatives were matched to 35 consecutive palatally displaced canine probands and 115 first-degree relatives. These were assessed for palatally displaced canines and incisor-premolar hypodontia. Parental age at birth of the proband was also noted. The results revealed that (i) there is no difference in the overall prevalence of palatally displaced canine or incisor-premolar hypodontia between the groups of relatives; (ii) first-degree relatives of bilateral palatally displaced canine probands have a higher prevalence of palatally displaced canine and incisor-premolar hypodontia than those with unilateral palatally displaced canine; and (iii) maternal age at birth of the maxillary canine - first premolar transposition probands was significantly higher than that of the palatally displaced canine probands. The results suggest that maxillary canine - first premolar transposition and palatally displaced canine are unlikely to be different genetic entities and also indicate environmental or epigenetic influences on dental development.

KW - Ectopic

KW - Epigenomics

KW - Genetics

KW - Hypodontia

KW - Orthodontics

KW - Tooth eruption

UR - http://www.scopus.com/inward/record.url?scp=84959376948&partnerID=8YFLogxK

U2 - 10.1038/ijos.2014.72

DO - 10.1038/ijos.2014.72

M3 - Article

AN - SCOPUS:84959376948

SN - 1674-2818

VL - 7

SP - 169

EP - 173

JO - International Journal of Oral Science

JF - International Journal of Oral Science

IS - 3

ER -