Dental anomalies in non-syndromic orofacial clefts: A clinical approach

Lucimara Teixeira das Neves*, Izabel Maria Marchi de Carvalho, Martyn T. Cobourne, Marcia Ribeiro Gomide

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)


Orofacial clefts (OC) represent some of the most common congenital malformations and affect multiple structures in the craniofacial region. There are a wide range of morphological OC types within the spectrum of both non-syndromic OC (NSOC) and syndromic OC, including cleft lip (CL), cleft lip and palate, (CLP), and cleft palate (CP). Here, we describe the most frequent dental anomalies seen in the permanent dentition of individuals with NSOC, comparing them between the three main cleft types (CL, CLP, and CP). We present these findings from the perspective of prevalence relating to each anomaly, as well as the clinical characteristics and potential impact on the rehabilitation process. The investigation of dental anomalies associated with NSOC is important, helping to expand the phenotypic characterization of NSOC, improve the initial diagnostics, and establish appropriate rehabilitation and counseling.

Original languageEnglish
Pages (from-to)1351-1368
Number of pages18
JournalOral Diseases
Issue number5
Publication statusPublished - Jul 2022


  • clinical approach
  • dental anomalies
  • non-syndromic
  • orofacial cleft
  • permanent teeth


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