Dental stem cells for tooth regeneration and repair

TY - JOUR

T1 - Dental stem cells for tooth regeneration and repair

AU - Mantesso, Andrea

AU - Sharpe, Paul

PY - 2009/9

Y1 - 2009/9

N2 - Mesenchymal stem cells (MSCs) resident in bone marrow are one of the most studied and clinically important populations of adult stem cells. Cells with, similar proper-ties to these MSCs have been described in several different tooth tissues and the potential ease with which these dental MSCs could be obtained from patients has prompted great interest in these cells as a source of MSCs for cell-based therapeutics. In this review we address the current state of knowledge regarding these cells, their properties, origins, locations, functions and potential uses in tooth tissue engineering and repair. We discuss some of the key controversies and outstanding issues, not least of which whether dental stem cells actually exist.

AB - Mesenchymal stem cells (MSCs) resident in bone marrow are one of the most studied and clinically important populations of adult stem cells. Cells with, similar proper-ties to these MSCs have been described in several different tooth tissues and the potential ease with which these dental MSCs could be obtained from patients has prompted great interest in these cells as a source of MSCs for cell-based therapeutics. In this review we address the current state of knowledge regarding these cells, their properties, origins, locations, functions and potential uses in tooth tissue engineering and repair. We discuss some of the key controversies and outstanding issues, not least of which whether dental stem cells actually exist.

U2 - 10.1517/14712590903103795

DO - 10.1517/14712590903103795

M3 - Literature review

VL - 9

SP - 1143

EP - 1154

JO - EXPERT OPINION ON BIOLOGICAL THERAPY

JF - EXPERT OPINION ON BIOLOGICAL THERAPY

IS - 9

ER -