Dentoalveolar radiation dose following IMRT in oropharyngeal cancer-An observational study

TY - JOUR

T1 - Dentoalveolar radiation dose following IMRT in oropharyngeal cancer-An observational study

AU - Patel, Vinod

AU - Humbert-Vidan, Laia

AU - Thomas, Christopher

AU - Sassoon, Isabel

AU - McGurk, Mark

AU - Fenlon, Michael

AU - Urbano, Teresa Guerrero

N1 - © 2021 Special Care Dentistry Association and Wiley Periodicals LLC.

PY - 2021/5/1

Y1 - 2021/5/1

N2 - OBJECTIVES: This observational study aims to determine individual dental doses in oropharyngeal cancer (OPC) patients managed by intensity modulated radiation treatment (IMRT).MATERIALS AND METHODS: OPC patients treated with IMRT had each tooth individually contoured on post-IMRT CT scans. The mean, maximum and minimum doses were calculated per tooth-based upon patient and tumor demographics (tumor size and nodal status).RESULTS: A total of 160 patients were included in this study. Escalating tumor size and nodal status led to an observed increase in Dmean doses to the dentition on the contralateral tumor side. A significant region in both jaws received >30 Gy in this tumor group.CONCLUSION: Tumor demographics were observed to influence RT doses to the dentition and need to be considered when providing a pre-RT dental assessment. The observed dose of >30 Gy in large spans of the dentition and jaws highlights future risk of dental deterioration and ORN with long term survival.

AB - OBJECTIVES: This observational study aims to determine individual dental doses in oropharyngeal cancer (OPC) patients managed by intensity modulated radiation treatment (IMRT).MATERIALS AND METHODS: OPC patients treated with IMRT had each tooth individually contoured on post-IMRT CT scans. The mean, maximum and minimum doses were calculated per tooth-based upon patient and tumor demographics (tumor size and nodal status).RESULTS: A total of 160 patients were included in this study. Escalating tumor size and nodal status led to an observed increase in Dmean doses to the dentition on the contralateral tumor side. A significant region in both jaws received >30 Gy in this tumor group.CONCLUSION: Tumor demographics were observed to influence RT doses to the dentition and need to be considered when providing a pre-RT dental assessment. The observed dose of >30 Gy in large spans of the dentition and jaws highlights future risk of dental deterioration and ORN with long term survival.

UR - http://www.scopus.com/inward/record.url?scp=85100850654&partnerID=8YFLogxK

U2 - 10.1111/scd.12578

DO - 10.1111/scd.12578

M3 - Article

C2 - 33576541

SN - 0275-1879

VL - 41

SP - 319

EP - 326

JO - SPECIAL CARE IN DENTISTRY

JF - SPECIAL CARE IN DENTISTRY

IS - 3

ER -