Dependence in Alzheimer's disease and service use costs, quality of life, and caregiver burden: The DADE study

TY - JOUR

T1 - Dependence in Alzheimer's disease and service use costs, quality of life, and caregiver burden

T2 - The DADE study

AU - Jones, Roy W.

AU - Romeo, Renee

AU - Trigg, Richard

AU - Knapp, Martin

AU - Sato, Azusa

AU - King, Derek

AU - Niecko, Timothy

AU - Lacey, Loretto

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Background Most models determining how patient and caregiver characteristics and costs change with Alzheimer's disease (AD) progression focus on one aspect, for example, cognition. AD is inadequately defined by a single domain; tracking progression by focusing on a single aspect may mean other important aspects are insufficiently addressed. Dependence has been proposed as a better marker for following disease progression. Methods This was a cross-sectional observational study (18 UK sites). Two hundred forty-nine community or institutionalized patients, with possible/probable AD, Mini-Mental State Examination (3-26), and a knowledgeable informant participated. Results Significant associations noted between dependence (Dependence Scale [DS]) and clinical measures of severity (cognition, function, and behavior). Bivariate and multivariate models demonstrated significant associations between DS and service use cost, patient quality of life, and caregiver perceived burden. Conclusion The construct of dependence may help to translate the combined impact of changes in cognition, function, and behavior into a more readily interpretable form. The DS is useful for assessing patients with AD in clinical trials/research.

AB - Background Most models determining how patient and caregiver characteristics and costs change with Alzheimer's disease (AD) progression focus on one aspect, for example, cognition. AD is inadequately defined by a single domain; tracking progression by focusing on a single aspect may mean other important aspects are insufficiently addressed. Dependence has been proposed as a better marker for following disease progression. Methods This was a cross-sectional observational study (18 UK sites). Two hundred forty-nine community or institutionalized patients, with possible/probable AD, Mini-Mental State Examination (3-26), and a knowledgeable informant participated. Results Significant associations noted between dependence (Dependence Scale [DS]) and clinical measures of severity (cognition, function, and behavior). Bivariate and multivariate models demonstrated significant associations between DS and service use cost, patient quality of life, and caregiver perceived burden. Conclusion The construct of dependence may help to translate the combined impact of changes in cognition, function, and behavior into a more readily interpretable form. The DS is useful for assessing patients with AD in clinical trials/research.

KW - Alzheimer's disease

KW - Caregiver burden

KW - Dependence

KW - England

KW - Pharmacoeconomics

KW - Quality of life

KW - Service use costs

UR - http://www.scopus.com/inward/record.url?scp=84925937784&partnerID=8YFLogxK

U2 - 10.1016/j.jalz.2014.03.001

DO - 10.1016/j.jalz.2014.03.001

M3 - Article

AN - SCOPUS:84925937784

SN - 1552-5260

VL - 11

SP - 280

EP - 290

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

IS - 3

ER -